Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana

Chemical evaluation of the semi-purified fraction from the seeds of guaraná, Paullinia cupana H.B.K. var. sorbilis (Mart.) Ducke, yielded the following compounds: caffeine, catechin, epicatechin, ent-epicatechin, and procyanidins B1, B2, B3, B4, A2, and C1. Measurement of the antioxidant activity by...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2007-08, Vol.12 (8), p.1950-1963
Main Authors: Yamaguti-Sasaki, Elza, Ito, Lia Akina, Canteli, Vanessa Cristina Dias, Ushirobira, Tânia Mara Antonelli, Ueda-Nakamura, Tânia, Dias Filho, Benedito Prado, Nakamura, Celso Vataru, de Mello, João Carlos Palazzo
Format: Article
Language:English
Subjects:
antioxidant capacity
Antioxidants
Antioxidants - isolation & purification
Antioxidants - pharmacology
Caffeine
Cocoa
condensed tannins
Dental plaque
Dental Plaque - microbiology
Dental Plaque - prevention & control
Humans
Mass spectrometry
methylxanthines
Paullinia - chemistry
Paullinia cupana
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Prevention
prevention of the formation of dental plaque
Scientific imaging
Seeds
Streptococcus mutans - drug effects
Tannins - pharmacology
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container_end_page 1963
container_issue 8
container_start_page 1950
container_title Molecules (Basel, Switzerland)
container_volume 12
creator Yamaguti-Sasaki, Elza
Ito, Lia Akina
Canteli, Vanessa Cristina Dias
Ushirobira, Tânia Mara Antonelli
Ueda-Nakamura, Tânia
Dias Filho, Benedito Prado
Nakamura, Celso Vataru
de Mello, João Carlos Palazzo
description Chemical evaluation of the semi-purified fraction from the seeds of guaraná, Paullinia cupana H.B.K. var. sorbilis (Mart.) Ducke, yielded the following compounds: caffeine, catechin, epicatechin, ent-epicatechin, and procyanidins B1, B2, B3, B4, A2, and C1. Measurement of the antioxidant activity by reduction of the DPPH radical confirmed the anti-radical properties of the aqueous (AqE) and crude (EBPC) extracts and semi-purified (EPA and EPB) fractions. The EPA fraction showed radical-scavenging activity (RSA) and protected DPPH from discoloration at 5.23 +/- 0.08 (RSD% = 1.49) microg/mL, and for the phosphomolybdenum complex showed a higher Relative Antioxidant Capacity (RAC) at 0.75 +/- 0.01 (1.75). The EPA fraction had a total polyphenolics content of 65.80% +/- 0.62 (RSD% = 0.93). The plant drug showed 5.47% +/- 0.19 (RSD% = 3.51) and 6.19% +/- 0.08 (RSD% = 1.29) for total polyphenolics and methylxanthines, respectively. In vitro assessment of the antibacterial potential of the Paullinia cupana extracts against Streptococcus mutans showed that these could be used in the prevention of bacterial dental plaque.
doi_str_mv 10.3390/12081950
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In vitro assessment of the antibacterial potential of the Paullinia cupana extracts against Streptococcus mutans showed that these could be used in the prevention of bacterial dental plaque.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/12081950</identifier><identifier>PMID: 17960098</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>antioxidant capacity ; Antioxidants ; Antioxidants - isolation &amp; purification ; Antioxidants - pharmacology ; Caffeine ; Cocoa ; condensed tannins ; Dental plaque ; Dental Plaque - microbiology ; Dental Plaque - prevention &amp; control ; Humans ; Mass spectrometry ; methylxanthines ; Paullinia - chemistry ; Paullinia cupana ; Plant Extracts - isolation &amp; purification ; Plant Extracts - pharmacology ; Prevention ; prevention of the formation of dental plaque ; Scientific imaging ; Seeds ; Streptococcus mutans - drug effects ; Tannins - pharmacology</subject><ispartof>Molecules (Basel, Switzerland), 2007-08, Vol.12 (8), p.1950-1963</ispartof><rights>Copyright MDPI AG 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-ebb5d8e238cae8e1cceefdc83d434cad773315773a39784afc904fc8bab567e63</citedby><cites>FETCH-LOGICAL-c475t-ebb5d8e238cae8e1cceefdc83d434cad773315773a39784afc904fc8bab567e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1531128026/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1531128026?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17960098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguti-Sasaki, Elza</creatorcontrib><creatorcontrib>Ito, Lia Akina</creatorcontrib><creatorcontrib>Canteli, Vanessa Cristina Dias</creatorcontrib><creatorcontrib>Ushirobira, Tânia Mara Antonelli</creatorcontrib><creatorcontrib>Ueda-Nakamura, Tânia</creatorcontrib><creatorcontrib>Dias Filho, Benedito Prado</creatorcontrib><creatorcontrib>Nakamura, Celso Vataru</creatorcontrib><creatorcontrib>de Mello, João Carlos Palazzo</creatorcontrib><title>Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Chemical evaluation of the semi-purified fraction from the seeds of guaraná, Paullinia cupana H.B.K. var. sorbilis (Mart.) 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subjects antioxidant capacity
Antioxidants
Antioxidants - isolation & purification
Antioxidants - pharmacology
Caffeine
Cocoa
condensed tannins
Dental plaque
Dental Plaque - microbiology
Dental Plaque - prevention & control
Humans
Mass spectrometry
methylxanthines
Paullinia - chemistry
Paullinia cupana
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Prevention
prevention of the formation of dental plaque
Scientific imaging
Seeds
Streptococcus mutans - drug effects
Tannins - pharmacology
title Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana
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