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Attenuation of Haematological and Biochemical Alterations in Alloxan-Induced Diabetic Rats Using Ethanol Extract from Annona senegalensis Persoon (Annonaceae) Leaves

Chronic hyperglycemia brought on by abnormalities in insulin production, insulin action, or both is a typical symptom of diabetes mellitus. This study evaluated the ethanol leaf extract of A. senegalensis for its potential hypoglycaemic, anti-oxidative, and haematological activities in alloxan-induc...

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Bibliographic Details
Published in:Engineering proceedings 2023-12, Vol.56 (1), p.263
Main Authors: Osmund Chukwuma Enechi, Emmanuel Sunday Okeke, Destiny Chidiebere Arum, Stephen Chijioke Emencheta
Format: Article
Language:English
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Summary:Chronic hyperglycemia brought on by abnormalities in insulin production, insulin action, or both is a typical symptom of diabetes mellitus. This study evaluated the ethanol leaf extract of A. senegalensis for its potential hypoglycaemic, anti-oxidative, and haematological activities in alloxan-induced diabetic rats, as well as the effects of the extract on the lipid profile, liver, and kidney functions of the rats. Following diabetic induction and treatment of the rats, standard procedures were used in determining the red blood cell/erythrocyte count, white blood cell/leukocyte count, platelets, neutrophils, monocytes and eosinophils, electrolytes (sodium, potassium, chloride, and bicarbonate), lipid profile parameters (total cholesterol, triacylglycerides, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein), and kidney and liver function parameters (alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase activities, total protein, total bilirubin serum levels, creatinine, and urea serum levels). There was a reduction in the hyperglycaemic index and significant (p < 0.05) elevations in the antioxidant activity and haematological parameters. Na+ and high-density lipoprotein were, respectively, significantly (p < 0.05) reduced and elevated. There was a significant (p < 0.05) decrease in the kidney and liver function parameters. The study opens the door for further studies, including the elucidation of the bioactive compounds responsible for the observed pharmacological effects.
ISSN:2673-4591
DOI:10.3390/ASEC2023-16524