Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines

Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native β-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether β-CD...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2022-10, Vol.14 (11), p.2283
Main Authors: Abdelkader, Hamdy, Fatease, Adel Al, Fathalla, Zeinab, Shoman, Mai E, Abou-Taleb, Heba A, Abourehab, Mohammed A. S
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Breast cancer
curcumin
Cyclodextrins
Cytotoxicity
Dosage and administration
Drug therapy
Drugs
Health aspects
hydroxyethyl β-cyclodextrin
Investigations
MCF-7
Patient outcomes
Prostate
solubility
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native β-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether β-CD), hydroxypropyl β-cyclodextrin, and hydroxyethyl β-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl β-cyclodextrin, and curcumin: hydroxypropyl β-cyclodextrin were 7.33, 7.28, and 19.05 µg/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl β-cyclodextrin complex on the direct cell lines of MCF-7.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14112283