The Impact of Curcumin on Immune Response: An Immunomodulatory Strategy to Treat Sepsis

Primary and secondary immunodeficiencies cause an alteration in the immune response which can increase the rate of infectious diseases and worsened prognoses. They can also alter the immune response, thus, making the infection even worse. Curcumin is the most biologically active component of the tur...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (23), p.14710
Main Authors: Allegra, Alessandro, Mirabile, Giuseppe, Ettari, Roberta, Pioggia, Giovanni, Gangemi, Sebastiano
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial agents
Apoptosis
B cells
Biological activity
Clinical trials
Communicable Diseases - drug therapy
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Cytokines
Cytokines - metabolism
Dendritic cells
Epigenetics
Gene expression
Genetic analysis
Humans
Immune system
Immunity
Immunodeficiency
Immunology
Immunomodulation
Infections
Infectious diseases
Inflammation
Kinases
Lymphocytes
Macrophages
Metabolic pathways
Microorganisms
Natural killer cells
Oxidative stress
Pathogens
primary immunodeficiency
Prophylaxis
Review
secondary immunodeficiency
Sepsis
Sepsis - drug therapy
T cells
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Summary:Primary and secondary immunodeficiencies cause an alteration in the immune response which can increase the rate of infectious diseases and worsened prognoses. They can also alter the immune response, thus, making the infection even worse. Curcumin is the most biologically active component of the turmeric root and appears to be an antimicrobial agent. Curcumin cooperates with various cells such as macrophages, dendritic cells, B, T, and natural killer cells to modify the body's defence capacity. Curcumin also inhibits inflammatory responses by suppressing different metabolic pathways, reduces the production of inflammatory cytokines, and increases the expression of anti-inflammatory cytokines. Curcumin may also affect oxidative stress and the non-coding genetic material. This review analyses the relationships between immunodeficiency and the onset of infectious diseases and discusses the effects of curcumin and its derivatives on the immune response. In addition, we analyse some of the preclinical and clinical studies that support its possible use in prophylaxis or in the treatment of infectious diseases. Lastly, we examine how nanotechnologies can enhance the clinical use of curcumin.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232314710