Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium

• Published in: EBioMedicine 2015-11, Vol.2 (11), p.1677-1685
• Main Authors: Huang, Ruyi, Wei, Yongyue, Hung, Rayjean J., Liu, Geoffrey, Su, Li, Zhang, Ruyang, Zong, Xuchen, Zhang, Zuo-Feng, Morgenstern, Hal, Brüske, Irene, Heinrich, Joachim, Hong, Yun-Chul, Kim, Jin Hee, Cote, Michele, Wenzlaff, Angela, Schwartz, Ann G., Stucker, Isabelle, Mclaughlin, John, Marcus, Michael W., Davies, Michael P.A., Liloglou, Triantafillos, Field, John K., Matsuo, Keitaro, Barnett, Matt, Thornquist, Mark, Goodman, Gary, Wang, Yi, Chen, Size, Yang, Ping, Duell, Eric J., Andrew, Angeline S., Lazarus, Philip, Muscat, Joshua, Woll, Penella, Horsman, Janet, Dawn Teare, M., Flugelman, Anath, Rennert, Gad, Zhang, Yan, Brenner, Hermann, Stegmaier, Christa, van der Heijden, Erik H.F.M., Aben, Katja, Kiemeney, Lambertus, Barros-Dios, Juan, Pérez-Ríos, Monica, Ruano-Ravina, Alberto, Caporaso, Neil E., Bertazzi, Pier Alberto, Landi, Maria Teresa, Dai, Juncheng, Shen, Hongbing, Fernandez-Tardon, Guillermo, Rodriguez-Suarez, Marta, Tardon, Adonina, Christiani, David C.
• Format: Article
• Language: English
• Subjects: Aged; Case-Control Studies; Causal mediation analysis; Chronic obstructive pulmonary disease; Female; Humans; Lung Neoplasms - epidemiology; Lung Neoplasms - etiology; Male; Middle Aged; Models, Biological; Multicenter pooling; Odds Ratio; Population Surveillance; Pulmonary Disease, Chronic Obstructive - complications; Risk; Small cell lung cancer risk; Small Cell Lung Carcinoma - epidemiology; Small Cell Lung Carcinoma - etiology; Smoking - adverse effects; Smoking behaviors; Time Factors
• ISSN: 2352-3964; 2352-3964
• DOI: 10.1016/j.ebiom.2015.09.031

The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Significant dose–response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5–9years to 89%quit_for_≥20years declined SCLC risk vs. subjects who had quit smoking