Administration of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934, Two Strains Isolated from Human Milk, to Very Low and Extremely Low Birth Weight Preterm Infants: A Pilot Study

The preterm infant gut has been described as immature and colonized by an aberrant microbiota. Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of...

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Published in:Journal of immunology research 2015-01, Vol.2015 (2015), p.1-12
Main Authors: Espinosa-Martos, Irene, Jiménez, Esther, Rodríguez, Juan Miguel, Montes, María Teresa, de Andrés, Javier, Escribano, Esperanza, Moles, Laura, Sáenz de Pipaón, Miguel
Format: Article
Language:English
Subjects:
Babies
Bifidobacterium - isolation & purification
Bifidobacterium breve
Biodiversity
Birth weight
Cluster Analysis
Female
Firmicutes
Gastrointestinal Microbiome - immunology
Humans
Immunity
Immunology
Infant, Extremely Low Birth Weight - immunology
Infant, Newborn
Infant, Very Low Birth Weight - immunology
Lactobacillus - isolation & purification
Lactobacillus salivarius
Metabolic disorders
Milk
Milk, Human - microbiology
Mortality
Pilot Projects
Premature birth
Probiotics - administration & dosage
Studies
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creator Espinosa-Martos, Irene
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Rodríguez, Juan Miguel
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Sáenz de Pipaón, Miguel
description The preterm infant gut has been described as immature and colonized by an aberrant microbiota. Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of two probiotic strains isolated from human milk to preterm infants led to their presence in feces. In addition, the evolution of a wide spectrum of immunological compounds, including the inflammatory biomarker calprotectin, in both blood and fecal samples was also assessed. For this purpose, five preterm infants received two daily doses (~109 CFU) of a 1 : 1 mixture of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934. Bacterial growth was detected by culture-dependent techniques in all the fecal samples. The phylum Firmicutes dominated in nearly all fecal samples while L. salivarius PS12934 was detected in all the infants at numerous sample collection points and B. breve PS12929 appeared in five fecal samples. Finally, a noticeable decrease in the fecal calprotectin levels was observed along time.
doi_str_mv 10.1155/2015/538171
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Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of two probiotic strains isolated from human milk to preterm infants led to their presence in feces. In addition, the evolution of a wide spectrum of immunological compounds, including the inflammatory biomarker calprotectin, in both blood and fecal samples was also assessed. For this purpose, five preterm infants received two daily doses (~109 CFU) of a 1 : 1 mixture of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934. Bacterial growth was detected by culture-dependent techniques in all the fecal samples. The phylum Firmicutes dominated in nearly all fecal samples while L. salivarius PS12934 was detected in all the infants at numerous sample collection points and B. breve PS12929 appeared in five fecal samples. Finally, a noticeable decrease in the fecal calprotectin levels was observed along time.</description><identifier>ISSN: 2314-8861</identifier><identifier>EISSN: 2314-7156</identifier><identifier>DOI: 10.1155/2015/538171</identifier><identifier>PMID: 25759843</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Babies ; Bifidobacterium - isolation &amp; purification ; Bifidobacterium breve ; Biodiversity ; Birth weight ; Cluster Analysis ; Female ; Firmicutes ; Gastrointestinal Microbiome - immunology ; Humans ; Immunity ; Immunology ; Infant, Extremely Low Birth Weight - immunology ; Infant, Newborn ; Infant, Very Low Birth Weight - immunology ; Lactobacillus - isolation &amp; purification ; Lactobacillus salivarius ; Metabolic disorders ; Milk ; Milk, Human - microbiology ; Mortality ; Pilot Projects ; Premature birth ; Probiotics - administration &amp; dosage ; Studies</subject><ispartof>Journal of immunology research, 2015-01, Vol.2015 (2015), p.1-12</ispartof><rights>Copyright © 2015 Laura Moles et al.</rights><rights>Copyright © 2015 Laura Moles et al. 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subjects Babies
Bifidobacterium - isolation & purification
Bifidobacterium breve
Biodiversity
Birth weight
Cluster Analysis
Female
Firmicutes
Gastrointestinal Microbiome - immunology
Humans
Immunity
Immunology
Infant, Extremely Low Birth Weight - immunology
Infant, Newborn
Infant, Very Low Birth Weight - immunology
Lactobacillus - isolation & purification
Lactobacillus salivarius
Metabolic disorders
Milk
Milk, Human - microbiology
Mortality
Pilot Projects
Premature birth
Probiotics - administration & dosage
Studies
title Administration of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934, Two Strains Isolated from Human Milk, to Very Low and Extremely Low Birth Weight Preterm Infants: A Pilot Study
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