Impairment of pulmonary microvascular endothelial cells: The ground for COPD?

[...]PMECs are essential for the integrity of the pulmonary blood–gas barrier, facilitating efficient gas exchange. [...]PMECs possess repair and regeneration capabilities, but chronic exposure to damaging stimuli in COPD impairs these processes, highlighting the importance of maintaining PMEC funct...

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Bibliographic Details
Published in:Chinese medical journal 2024-10, Vol.137 (19), p.2369-2371
Main Authors: Qi, Hui, Hou, Yunlong, Han, Ningxin, Jin, Peipei, Guo, Jing, Wang, Tongxing, Jia, Zhenhua
Format: Article
Language:English
Subjects:
Apoptosis
Chinese medicine
Chronic obstructive pulmonary disease
Correspondence
Drugs
Emphysema
Endothelium
Homeostasis
Inflammation
Kinases
Nitric oxide
Oxidative stress
Pathogenesis
Permeability
Pulmonary arteries
Pulmonary hypertension
Veins & arteries
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Summary:[...]PMECs are essential for the integrity of the pulmonary blood–gas barrier, facilitating efficient gas exchange. [...]PMECs possess repair and regeneration capabilities, but chronic exposure to damaging stimuli in COPD impairs these processes, highlighting the importance of maintaining PMEC function to mitigate disease progress. [...]impairment of PMECs leads to vascular barrier defects, alveolar damage, and pulmonary inflammation, which are preceding the decline in lung function, thereby indicating that PMEC injury is pivotal in COPD development and progression. [...]the insufficient efficacy of vasoactive drugs in COPD treatment may be due to a mismatched intervention time window. [...]due to the heterogeneity of PMECs, therapies targeting endothelial dysfunction require further refinement.
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/CM9.0000000000003280