Deficient IL-2 Produced by Activated CD56 + T Cells Contributes to Impaired NK Cell-Mediated ADCC Function in Chronic HIV-1 Infection

Antibody-dependent cellular cytotoxicity (ADCC), which mainly mediated by natural killer (NK) cells, may play a critical role in human immunodeficiency virus type-1 (HIV-1) disease progression. However, the potential mechanisms that affecting NK-mediated ADCC response are still not well-elucidated....

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2019-07, Vol.10, p.1647-1647
Main Authors: Xie, Zhe, Zheng, Jiajia, Wang, Yuya, Li, Dan, Maermaer, Tuohutaerbieke, Li, Yuantao, Tu, Jing, Xu, Qiang, Liang, Hua, Cai, Weiping, Shen, Tao
Format: Article
Language:English
Subjects:
ADCC
CD56+T cells
HIV-1
IL-2
Immunology
NK cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antibody-dependent cellular cytotoxicity (ADCC), which mainly mediated by natural killer (NK) cells, may play a critical role in human immunodeficiency virus type-1 (HIV-1) disease progression. However, the potential mechanisms that affecting NK-mediated ADCC response are still not well-elucidated. Antigen-antibody complex model of Ab-opsonized P815 cells was adopted to induce a typical non-specific ADCC response. The capacities of HIV-1 specific NK-ADCC were measured by using the combination model of gp120 protein and plasma of HIV-1 elite controllers. The levels of plasma cytokine were measured by ELISA. Anti-IL-2 blocking antibody was used to analyze the impact of activated CD56 T cells on NK-ADCC response. IL-2, IL-15, IFN-α, and IFN-β could effectively enhance the non-specific and HIV-1-specific NK-ADCC responses. Compared with healthy controls, HIV-1-infected patients showed decreased plasma IL-2 levels, while no differences of plasma IFN-α, IL-15, and IFN-β were presented. IL-2 production was detected from CD56 T cells activated through antibody-dependent manner. The capability of NK-ADCC could be weakened by blocking IL-2 secretion from activated CD56 T cells. Although no difference of frequencies of CD56 T cells was found between HIV-1-infected patients and healthy controls, deficient IL-2 secretion from activated CD56 T were found in chronic HIV-1 infection. The impaired ability of activated CD56 T cells to secreting IL-2 might contribute to the attenuated NK cell-mediated ADCC function in HIV-1 infection.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.01647