Role of atrial natriuretic peptide in the dissociation between flow relations with ventricular mass and function in a community with volume-dependent hypertension

Whether differential effects of volume load on left ventricular mass (LVM) and function occur in sustained volume-dependent primary hypertension, and the impact of atrial natriuretic peptide (ANP) on these effects, is unknown. From aortic pressure, velocity and diameter measurements and echocardiogr...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2023-05, Vol.10, p.1175145-1175145
Main Authors: Yusuf, Suraj M, Norton, Gavin R, Peterson, Vernice R, Mthembu, Nonhlanhla, Libhaber, Carlos D, Tade, Grace, Bello, Hamza, Bamaiyi, Adamu J, Mmopi, Keneilwe N, Dessein, Patrick H, Peters, Ferande, Sareli, Pinhas, Woodiwiss, Angela J
Format: Article
Language:English
Subjects:
atrial natriuretic peptide
Cardiovascular Medicine
diastolic function
left ventricular mass
stroke volume
systolic function
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Summary:Whether differential effects of volume load on left ventricular mass (LVM) and function occur in sustained volume-dependent primary hypertension, and the impact of atrial natriuretic peptide (ANP) on these effects, is unknown. From aortic pressure, velocity and diameter measurements and echocardiography, we determined in an African community (  = 772), the impact of systemic flow-induced increases in central pulse pressure (PPc) and circulating ANP (ELISA) on LVM and indexes of function. Stroke volume (SV), but not aortic flow (Q), was associated with LVM and mean wall thickness (MWT) beyond stroke work and confounders (  
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2023.1175145