Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

• Published in: BMEmat (Print) 2024-02, Vol.2 (1), p.n/a
• Main Authors: Cui, Mingjin, Xu, Bo, Wang, Lianhui
• Format: Article
• Language: English
• Subjects: Apoptosis; Cancer therapies; cancer therapy; Cell death; Enzyme kinetics; Glucose; Magnetic resonance imaging; Metals; Microscopy; multi‐metallic nanomaterials; Nanomaterials; Nanoparticles; nanozyme activities; synergistic effects
• ISSN: 2751-7446; 2751-7438; 2751-7446
• DOI: 10.1002/bmm2.12043

Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing natural enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest and exploration in the utilization of nanozymes for targeted cancer treatment. Recent advancements in interdisciplinary research, nanotechnology, biotechnology, and catalytic technology have led to the emergence of multi‐metallic‐based nanozymes, which exhibit tremendous potential for further development. This review focuses on investigating the synergistic effects of multi‐metallic‐based nanozymes, aiming to enhance our understanding of their catalytic activities and facilitate their broader applications. We comprehensively survey the remarkable achievements in the synthesis, catalytic mechanisms, and the latest applications of multi‐metallic‐based nanozymes in cancer catalytic therapy. Furthermore, we identify the current limitations and prospects of multi‐metallic‐based nanozymes in the development of new materials and the application of novel technologies, along with the potential challenges associated with catalytic cancer therapy. This review underscores the significance of multi‐metallic‐based nanozymes and emphasizes the need for continued exploration as well as their potential impact on the development of novel materials and the realization of breakthroughs in catalytic tumor therapy. This review highlights recent advancements in multi‐metallic‐based nanozymes, encompassing their fabrication, nanozyme activities, and applications in cancer therapy. The integration of multiple metal elements in the fabrication process results in unique structures with enhanced catalytic properties. By exploring the tunable electronic and structural characteristics of multi‐metallic‐based nanozymes, we elucidate their superior catalytic activities for efficient cancer therapy. Diverse applications include targeted cascade catalytic therapy, glutathione depletion, and starvation therapy, providing a comprehensive understanding of these nanozymes' potential for revolutionizing cancer treatment.