Immunological Risk Factors in Paediatric Kidney Transplantation

• Published in: Research and reports in urology 2021-01, Vol.13, p.87-95
• Main Authors: Friedersdorff, Frank, Banuelos-Marco, Beatriz, Koch, Marie-Therese, Lachmann, Nils, Bichmann, Anna, Miller, Kurt, Gonzalez, Ricardo, Müller, Dominik, Lingnau, Anja
• Format: Article
• Language: English
• Subjects: Age; Age groups; Biopsy; Blood transfusions; Body mass index; Creatinine; Cytomegalovirus; donor statistic; Donors; Graft rejection; graft survival; Hemodialysis; Histocompatibility antigen HLA; immunological risk factors; Immunoproliferative diseases; immunosuppression; Immunosuppressive agents; Ischemia; kidney transplant; Kidney transplantation; Kidney transplants; Kidneys; Lymphocytes; Medical records; Original Research; paediatric transplantation; Patients; Pediatrics; Posttransplant lymphoproliferative disorders; Regression analysis; Risk factors; Statistical analysis; Survival; Transplants & implants
• ISSN: 2253-2447; 2253-2447
• DOI: 10.2147/RRU.S289853

The aim of this study was to identify factors impacting recipient sensitization rates and paediatric renal transplant patient outcomes. For this purpose, a retrospective analysis of 143 paediatric renal transplants was carried out. This included the evaluation of patient's and donor's demographic data, HLA mismatches, immunosuppressive therapy, rejection episodes, panel reactive antibody (PRA) and post-transplant lymphoproliferative disease (PTLD). The mean patient age at the point of transplant receival was 11.5 years with a mean follow up time of 9.33±5.05 years. It was noted that graft survival rates for donors over 59 years had the worst outcome. HLA match did not show statistically significant influence on graft outcome. Graft survival for more than one biopsy-proven rejection was also significantly shorter (p=0.008). PRA were found in 28% of the recipient's post-transplantation and showed association with lower graft survival rates (p