Serum heparan sulfate levels are elevated in endotoxemia

Increased vascular permeability is a characteristic feature of sepsis which, in the past, has been ascribed exclusively to a malfunction of endothelial cells. However, recently it has become evident that the endothelial glycocalyx is of considerable importance concerning various aspects of vascular...

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Bibliographic Details
Published in:European journal of medical research 2009-12, Vol.14 (520), p.526-526, Article 526
Main Authors: Hofmann-Kiefer, Klaus F, Kemming, G I, Chappell, D, Flondor, M, Kisch-Wedel, H, Hauser, A, Pallivathukal, S, Conzen, P, Rehm, M
Format: Article
Language:English
Subjects:
Analysis
Animals
Endothelium
Endothelium, Vascular - chemistry
Endotoxemia - blood
Endotoxemia - chemically induced
Endotoxin
Endotoxins
Glycocalyx
Glycocalyx - chemistry
Heparan Sulfate
Heparitin Sulfate - blood
Infection
Inflammation
Interleukins
Leukocyte Adhesion
Permeability
Physiological aspects
Sepsis
Sulfates
Swine
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Summary:Increased vascular permeability is a characteristic feature of sepsis which, in the past, has been ascribed exclusively to a malfunction of endothelial cells. However, recently it has become evident that the endothelial glycocalyx is of considerable importance concerning various aspects of vascular physiology, e.g. the vascular barrier and inflammation. Heparan sulfate, one of its essential components is characteristically traceable in blood, in case the endothelial glycocalyx is damaged or destroyed. In 15 pigs we investigated whether the administration of endotoxin from gram-negative bacteria (Escherichia coli) results in increased serum levels of heparan sulfate, signalizing a shedding of the glycocalyx. In addition, markers of inflammation (white blood cell count, platelet count, tumour necrosis factor-α and interleukin-6) were evaluated over an observation period of 6 hours. Serum heparan sulfate concentrations significantly increased over time in the endotoxin group and were significantly elevated in comparison to the control group 6 hours after administration of endotoxin (p
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/2047-783x-14-12-526