Myomatrix arrays for high-definition muscle recording

• Published in: eLife 2023-12, Vol.12
• Main Authors: Chung, Bryce, Zia, Muneeb, Thomas, Kyle A, Michaels, Jonathan A, Jacob, Amanda, Pack, Andrea, Williams, Matthew J, Nagapudi, Kailash, Teng, Lay Heng, Arrambide, Eduardo, Ouellette, Logan, Oey, Nicole, Gibbs, Rhuna, Anschutz, Philip, Lu, Jiaao, Wu, Yu, Kashefi, Mehrdad, Oya, Tomomichi, Kersten, Rhonda, Mosberger, Alice C, O'Connell, Sean, Wang, Runming, Marques, Hugo, Mendes, Ana Rita, Lenschow, Constanze, Kondakath, Gayathri, Kim, Jeong Jun, Olson, William, Quinn, Kiara N, Perkins, Pierce, Gatto, Graziana, Thanawalla, Ayesha, Coltman, Susan, Kim, Taegyo, Smith, Trevor, Binder-Markey, Ben, Zaback, Martin, Thompson, Christopher K, Giszter, Simon, Person, Abigail, Goulding, Martyn, Azim, Eiman, Thakor, Nitish, O'Connor, Daniel, Trimmer, Barry, Lima, Susana Q, Carey, Megan R, Pandarinath, Chethan, Costa, Rui M, Pruszynski, J Andrew, Bakir, Muhannad, Sober, Samuel J
• Format: Article
• Language: English
• Subjects: Analysis; Animal behavior; Animals; Arrays; Behavior; Bengalese finch; Design optimization; electrode; Electrodes; EMG; frog; Gold; hawk moth; Mice; Motor neurons; Motor Neurons - physiology; motor systems; Motor task performance; Muscle Fibers, Skeletal; Muscles; Nervous system; Neurons; Neuroscience; Primates; Principal components analysis; Rats; Surgeons; Tools and Resources
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.88551

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output - the activation of muscle fibers by motor neurons - typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices ('Myomatrix arrays') that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a 'motor unit,' during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system's motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and identifying pathologies of the motor system.