Anti-Type VII Collagen Antibodies Are Identified in a Subpopulation of Bullous Pemphigoid Patients With Relapse

Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-typ...

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Bibliographic Details
Published in:Frontiers in immunology 2018-03, Vol.9, p.570-570
Main Authors: Giusti, Delphine, Gatouillat, Grégory, Le Jan, Sébastien, Plée, Julie, Bernard, Philippe, Antonicelli, Frank, Pham, Bach-Nga
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
anti-type VII collagen antibodies
Autoantibodies - blood
Autoantibodies - immunology
bullous pemphigoid
Collagen Type VII - immunology
Enzyme-Linked Immunosorbent Assay
epitope spreading
Female
Humans
Immunology
Life Sciences
Male
Middle Aged
Mucous Membrane - immunology
Mucous Membrane - metabolism
mucous membrane involvement
Pemphigoid, Bullous - blood
Pemphigoid, Bullous - immunology
Pemphigoid, Bullous - metabolism
Recurrence
relapse
Retrospective Studies
Skin - immunology
Skin - metabolism
Skin - pathology
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Summary:Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-type VII collagen AAbs. We therefore evaluated the presence of anti-type VII collagen AAbs in the serum of BP patients with and without mucosal lesions at time of diagnosis and under therapy. Anti-BP180, anti-BP230, and anti-type VII collagen AAbs were measured by ELISA in the serum of unselected patients fulfilling clinical and histo/immunopathological BP criteria at baseline (  = 71) and at time of relapse (  = 24). At baseline, anti-type VII collagen AAbs were detected in 2 out of 24 patients with BP presenting with mucosal involvement, but not in patients without mucosal lesions (  = 47). At the time of relapse, 10 out of 24 BP patients either displayed a significant induction or increase of concentrations of anti-type VII collagen AAbs (  
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.00570