Meibomian gland dysfunction in a case of ichthyosis follicularis with alopecia and photophobia syndrome

• Published in: Indian journal of ophthalmology 2014-03, Vol.62 (3), p.365-367
• Main Authors: Fatima, Tarannum, Mathur, Umang, Acharya, Manisha
• Format: Article
• Language: English
• Subjects: Abnormalities, Multiple; Absent thumb; Actinic granuloma; Age; Alopecia; Alopecia - complications; Alopecia - diagnosis; alopecia and photophobia syndrome; anterior segment dysgenesis; Aspergillosis; Atypical; Axenfeld-Rieger Syndrome; Bacterial conjunctivitis; Baldness; Barriers to follow-up; blepharophimosis ptosis epicanthus inversus syndrome; body mass index; Brief Communications; Capsular block syndrome; Capsular tension ring; Care and treatment; cataract; Central retinal vein occlusion; Child, Preschool; cholesterol granuloma; Clinical profile; Compressive optic neuropathy; conjunctiva; conjunctivitis; Contrast sensitivity; craniofacial defects; Decompression of the orbit; Diabetic macular edema; Diagnosis; diplopia; Dirofilaria; Disc edema; endophthalmitis; Ethnicity; Eyelid diseases; Eyelid Diseases - diagnosis; Eyelid Diseases - etiology; Eyelid Diseases - physiopathology; Eyelid retraction; Female; fixation; gender; glaucoma; gram negative diplococcus; granuloma annulare; Haptic fracture; high density lipoprotein; Homocysteine; Humans; humphrey visual field; Ichthyosis; Ichthyosis - complications; Ichthyosis - diagnosis; Ichthyosis follicularis; Indian; Indian population; Internal limiting membrane; intracameral mydriatic solution; intraocular dirofilaria; intraocular lens; intraocular pressure; intravitrealbevacizumab; intravitrealtriamcinolone acetonide; ischemic optic neuropathy; Keratitis; limbal dermoid; Limbus incision; lipid profiles; macular edema; macular hole; macular thickness; meibomian gland dysfunction; Meibomian Glands - physiopathology; microperimeter; monocyte chemoattractant protein-1; multifocal visual evoked potential; myopia; Nager syndrome; necrobiosis lipoidica; neem oil; Neisseria sicca; neonatal abscess; netilmicin; no preoperative mydriatic; normative; normative data; ocular invovement; Ocular torticollis; optic disc pit; optic neuritis; optic neuritis treatment trial; optic neuropathy; Optical coherence tomography; orbit; orbital infection; orbital neonatal abscess; pediatric cataract; phacoemulsification; Photophobia - complications; Photophobia - diagnosis; Polymerase chain reaction; posterior capsular opacification; posterior chamber intraocular lens fracture; putamen; re-surgery; retinal detachment; retinal nerve fiber layer; retinal sensitivity; retinal vein occlusion; retinoschisis; Rhodotorula sp; soluble intracellular adhesion molecule-1; spontaneous fracture; subconjunctival incision; superior oblique palsy; surgery; sutureless manual small-incision cataract surgery; Syndrome; thyroid exophthalmos; thyroid ophthalmopathy; total cholesterol; Toxic Optic Neuropathy Secondary to Consumption of Neem Oil; toxin-induced encephalopathy; triglyceride; vascular endothelial growth factor; Vision disorders; visual impairment; visual outcome; vitrectomy; voriconazole; worm; wound construction
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/0301-4738.116486

We are reporting an interesting case of ichthyosis follicularis with alopecia and photophobia syndrome in a daughter and father from the Indian subcontinent associated with Meibomian gland dysfunction. A three-year-old female child presented with pain, redness and severe photophobia in both eyes since one month. Cutaneous examination revealed ichthyosis, absence of hair all over the body including eyebrows, scalp and angular cheilosis. Ocular examination revealed bilateral severe meibomianitis, multiple superficial punctate keratitides in right eye and corneal epithelial defect in the left eye. Other systemic features were prominent high forehead and large ears. Her father had similar symptoms. Her symptoms improved after adequate treatment of meibomian gland dysfunction. She is asymptomatic at present.