Application of COOK® cervical ripening balloon combined with artificial rupture of membranes and oxytocin in labor induction for full-term pregnancy

• Published in: Traditional medicine and modern medicine 2022-12, Vol.5 (1n04), p.19-27
• Main Authors: Dong, Ying, Li, Chuyu, Zhao, Xin, Zhang, Lin, Jia, Xiaojun, Fu, Zhongxing, Du, Yan, Wang, Ling
• Format: Article
• Language: English
• Subjects: Adverse events; Analgesia; Apgar score; artificial rupture of membranes; Balloons; Birth weight; Cervix; COOK balloon; full-term pregnancy; Gestational age; Hemorrhage; Hormones; Induced labor; labor induction; Oxytocin; Pregnancy; Research Article; Rupture
• ISSN: 2575-9000; 2575-9019
• DOI: 10.1142/S2575900023500015

Objective: The use of COOK ® balloon in the process of induction of labor is gradually promoted. This study was conducted to investigate the safety and efficacy of COOK ® double balloon in promoting the maturity of uterine neck, and whether COOK ® double balloon can improve the success rate of induced labor. Methods: A total of 343 pregnant women with full-term pregnancy in Shanghai Putuo Maternity & Infant Health Hospital from January 1st to September 30th of 2016 were enrolled. Of all the pregnant women, 166 had labor induction, which included the use of a COOK ® balloon, the implementation of artificial rupture of membranes (AROM) and oxytocin intravenous (IV) drip (COOK ® group). The other 177 pregnant women with spontaneous rupture of membranes (SROM) and mature cervix only were administrated with oxytocin IV drip to promote regular uterus contraction (oxytocin group). Maternal adverse reactions, mode of delivery and delivery outcomes of two groups were subsequently compared between the two groups. Results: There were significant differences of maternal age ( 2 8 . 2 9 ± 3 . 3 4 versus 2 9 . 2 5 ± 3 . 6 2 years, P = 0 . 0 2 ), gestational age ( 2 8 3 . 4 9 ± 4 . 5 3 versus 2 7 4 . 7 1 ± 7 . 0 4 years, P < 0 . 0 0 1 ) and birth weight ( 3 4 3 5 . 2 7 ± 3 4 0 . 2 9 versus 3 3 5 4 . 6 3 ± 3 8 7 . 9 6 g, P = 0 . 0 2 ) between the COOK ® group and the oxytocin group. There were no significant differences in terms of gravidity, parity, mode of delivery, analgesia, 1 min and 5 min Apgar score, labor time, postpartum hemorrhage, and adverse events. Conclusion: Use of a COOK ® balloon may help in full-term pregnancy for women with immature cervix and to obtain the same pregnancy results as those with mature cervix, without extra occurrence of adverse events.