Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial

Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. Oral dentifrices have been marketed for pain relief within a minute for DH. The permanent management of DH is being investigated with the remineralisation potential of bioactive ag...

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Bibliographic Details
Published in:BMC oral health 2021-10, Vol.21 (1), p.498-12, Article 498
Main Authors: Arshad, Saba, Zaidi, Syed Jaffar Abbas, Farooqui, Waqas Ahmed
Format: Article
Language:English
Subjects:
Acetic acid
Arginine
Calcium phosphates
Care and treatment
Comparative analysis
Complex Mixtures
Dentifrices
Dentifrices - therapeutic use
Dentin
Dentin Desensitizing Agents - therapeutic use
Dentin Sensitivity - drug therapy
Dentine hypersensitivity
Double-Blind Method
Drug Combinations
Fluorides
Fluoro-calcium phospho-silicate
Health aspects
Health sciences
Humans
Hydroxyapatite
Hypersensitivity
Hypotheses
Mechanical stimuli
Meta-analysis
Nitrates
Pain
Phosphates
Physiological aspects
Potassium Compounds
Quality of Life
Sodium fluoride
Sodium Fluoride - therapeutic use
Statistical analysis
Strontium
Strontium acetate
Systematic review
Teeth
Testing
Toothache
Treatment Outcome
Tubules
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Summary:Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. Oral dentifrices have been marketed for pain relief within a minute for DH. The permanent management of DH is being investigated with the remineralisation potential of bioactive agents in dentinal tubules. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin™ and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. A randomised, controlled, triple-blinded clinical trial was conducted with 140 participants clinically diagnosed with DH and equally randomized into four groups with parallel treatment assignment of FCPS, Pro-Argin™, 8% strontium acetate, and sodium fluoride-based OTC dentifrices, and tested for DH with air blast, mechanical, and water jet stimuli on SCHIFF cold air sensitivity scale (SCASS) and visual analogue scale (VAS) at interim efficacy intervals of one minute, three days, two, four, and six weeks, subsequently. A total of 128 participants completed the trial. All the treatment groups showed statistically significant improvement in DH with p 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-021-01864-x