Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery

Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL. In recent years, DAMPs (damage-associa...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.3862
Main Authors: Caballero-Herrero, María José, Jumilla, Esther, Buitrago-Ruiz, Manuel, Valero-Navarro, Graciela, Cuevas, Santiago
Format: Article
Language:English
Subjects:
Alarmins
Alzheimer's disease
Anastomosis, Surgical - adverse effects
Anastomotic leak
Anastomotic Leak - etiology
Apoptosis
Colorectal Surgery
Complications and side effects
Crystal defects
Crystals
Cytokines
Damage patterns
damage-associated molecular patterns
Disease prevention
Gene expression
Homeostasis
Humans
Hypotheses
Immune system
Inflammasomes
Inflammation
Kinases
Metabolism
NLRP3 inflammasome
Pathogens
Postoperative Complications - prevention & control
Postoperative Period
Proteins
Review
Sensors
Surgery
Surgical anastomosis
Type 2 diabetes
Uric acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL. In recent years, DAMPs (damage-associated molecular patterns) have been identified as cellular compounds with the ability to activate the immune system. The NLRP3 inflammasome plays an important role in the inflammatory responses which are mediated by DAMPs such as ATP, HSP proteins or uric acid crystals, when found in extracellular environments. Recent publications suggest that systemic concentration of DAMPs in patients with colorectal surgery may determine the inflammatory process and have a role in the occurrence of AL and other post-surgery complications. This review provides valuable knowledge about the current evidence supporting this hypothesis and highlights the possible role of these compounds in postoperative processes, which could open a new path to explore new strategies to prevent possible post-surgical complications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043862