Novel-and Not So Novel-Inhibitors of the Multifunctional CRM1 Protein

Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex. CRM1 inhibition with small molecule inhibitors is currently being studied in many cancers, including leukemias,...

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Bibliographic Details
Published in:Oncology reviews 2024-08, Vol.18, p.1427497
Main Authors: Aumann, Waitman K, Kazi, Rafi, Harrington, Amanda M, Wechsler, Daniel S
Format: Article
Language:English
Subjects:
cancer
CRM1
leptomycin B
nuclear export
Oncology Reviews
XPO1
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Summary:Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex. CRM1 inhibition with small molecule inhibitors is currently being studied in many cancers, including leukemias, solid organ malignancies and brain tumors. We review the structure of CRM1, its role in nuclear export, the current availability of CRM1 inhibitors, and the role of CRM1 in a number of distinct cellular processes. A deeper understanding of how CRM1 functions in nuclear export as well as other cellular processes may allow for the development of additional novel CRM1 inhibitors.
ISSN:1970-5565
1970-5557
1970-5557
DOI:10.3389/or.2024.1427497