Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application

In this study, in order to enhance the aqueous solubility and to overcome the limitation of curcumin (Cur) in free form, as well as to develop a carrier for transdermal delivery of hydrophobic pharmaceutical agents such as Cur, a sonicated synthetic process of nanocurcumin (nCur) in thermally respon...

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Bibliographic Details
Published in:Green processing and synthesis 2016-12, Vol.5 (6), p.511-520
Main Authors: Nguyen, Thi Bich Tram, Dang, Le Hang, Nguyen, Thi Thanh Thuy, Tran, Dai Lam, Nguyen, Dai Hai, Nguyen, Van Toan, Nguyen, Cuu Khoa, Nguyen, Thi Hiep, Le, Van Thu, Tran, Ngoc Quyen
Format: Article
Language:English
Subjects:
biomedical application
chitosan
nanocurcumin
thermosensitive copolymer
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Summary:In this study, in order to enhance the aqueous solubility and to overcome the limitation of curcumin (Cur) in free form, as well as to develop a carrier for transdermal delivery of hydrophobic pharmaceutical agents such as Cur, a sonicated synthetic process of nanocurcumin (nCur) in thermally responsive Chitosan-g-Pluronic (CP) copolymer is disclosed herein. The use of CP copolymer solution as a dispersant medium is a very attractive method to avoid the use of toxic organic solvent and non-biocompatible surfactant. The obtained Cur nanoparticles had a fairly narrow distribution of 8–23 nm. nCur-dispersed CP solution showed good stability with no change in color characteristic and no phase separation after 1 month of storage. Rheological characterization of CP hydrogels had indicated sol-gel transition at the same temperature (35°C). Interestingly, the rate of Cur release for this system can be conveniently modulated as transdermal drug delivery.
ISSN:2191-9542
2191-9550
DOI:10.1515/gps-2016-0062