Dental loss, stress fractures, and musculoskeletal pain in a 48‐year‐old woman

We report a 48‐year‐old female patient with various stress fractures of extremities, musculoskeletal pain, and tooth loss. Hypophosphatasia was diagnosed based on clinical and laboratory findings and ALPL genetic results. This case highlights the importance of early diagnosis of hypophosphatasia in...

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Bibliographic Details
Published in:Clinical case reports 2023-03, Vol.11 (3), p.e7002-n/a
Main Authors: Hoang, Lindsay T., Hatfield, Jennifer S., Nguyen, Quan, Shakir, Mohamed K. M., Hoang, Thanh D.
Format: Article
Language:English
Subjects:
Adults
Case Image
Case Images
Case reports
Consent
dental loss
Edentulous
Editing
Fractures
low alkaline phosphatase
Medical imaging
Mineralization
Patients
Phosphatase
stress fracture
Teeth
Writing
X-rays
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Summary:We report a 48‐year‐old female patient with various stress fractures of extremities, musculoskeletal pain, and tooth loss. Hypophosphatasia was diagnosed based on clinical and laboratory findings and ALPL genetic results. This case highlights the importance of early diagnosis of hypophosphatasia in adults and appropriate treatment to prevent further complications. Adult hypophosphatasia may present with recurrent fractures, chronic musculoskeletal pain, tooth loss, and low alkaline phosphatase level. Asfotase alfa therapy can be used to improve respiratory function, motor function, and reduce tooth loss.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.7002