Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation

Background: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r). Objectives:...

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Bibliographic Details
Published in:Southern African journal of HIV medicine 2018, Vol.19 (1), p.1-6
Main Authors: Viljoen, Michelle, Du Plessis, Jesslee M., Greffrath, Wilhelm P., Cockeran, Marike
Format: Article
Language:English
Subjects:
Amylases
Antiretroviral agents
Biology
cardiovascular risk
Comparative analysis
Health aspects
Health Care Sciences & Services
Health Policy & Services
Highly active antiretroviral therapy
Hypertriglyceridaemia
Immunology
lopinavir/ritonavir
Original Research
Pancreatitis
Risk factors
Triglycerides
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Summary:Background: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r). Objectives: To evaluate the risk of pancreatitis associated with HTG in patients six months post initiation of LPV/r-based therapy in a regional public hospital. Methods: Triglyceride (TG), serum amylase (s-amylase) and CD4+ count values were retrospectively investigated six months post LPV/r-based initiation. Age, gender, previous antiretroviral regimen and period since HIV diagnosis were also recorded. Results: The final sample consisted of 194 patients, 50 males and 144 females; mean (± standard deviation [s.d.]) age was 39.52 (± 9.98) years, and the mean (± s.d.) period since HIV diagnosis was 91.32 (± 25.18) months. Normal TG levels (
ISSN:1608-9693
2078-6751
2078-6751
DOI:10.4102/sajhivmed.v19i1.766