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Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis
The aim of this study is to determine the effect that different tDCS protocols have on pain processing in healthy people, assessed using quantitative sensory tests (QST) and evoked pain intensity. We systematically searched in EMBASE, CINAHL, PubMed, PEDro, PsycInfo, and Web of Science. Articles on...
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| Published in: | Brain sciences 2024-01, Vol.14 (1), p.9 |
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| creator | Gurdiel-Álvarez, Francisco González-Zamorano, Yeray Lerma-Lara, Sergio Gómez-Soriano, Julio Sánchez-González, Juan Luis Fernández-Carnero, Josué Navarro-López, Víctor |
| description | The aim of this study is to determine the effect that different tDCS protocols have on pain processing in healthy people, assessed using quantitative sensory tests (QST) and evoked pain intensity.
We systematically searched in EMBASE, CINAHL, PubMed, PEDro, PsycInfo, and Web of Science. Articles on tDCS on a healthy population and regarding QST, such as pressure pain thresholds (PPT), heat pain thresholds (HPT), cold pain threshold (CPT), or evoked pain intensity were selected. Quality was analyzed using the Cochrane Risk of Bias Tool and PEDro scale.
Twenty-six RCTs were included in the qualitative analysis and sixteen in the meta-analysis. There were no significant differences in PPTs between tDCS and sham, but differences were observed when applying tDCS over S1 in PPTs compared to sham. Significant differences in CPTs were observed between tDCS and sham over DLPFC and differences in pain intensity were observed between tDCS and sham over M1. Non-significant effects were found for the effects of tDCS on HPTs.
tDCS anodic over S1 stimulation increases PPTs, while a-tDCS over DLPFC affects CPTs. The HPTs with tDCS are worse. Finally, M1 a-tDCS seems to reduce evoked pain intensity in healthy subjects. |
| doi_str_mv | 10.3390/brainsci14010009 |
| format | article |
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We systematically searched in EMBASE, CINAHL, PubMed, PEDro, PsycInfo, and Web of Science. Articles on tDCS on a healthy population and regarding QST, such as pressure pain thresholds (PPT), heat pain thresholds (HPT), cold pain threshold (CPT), or evoked pain intensity were selected. Quality was analyzed using the Cochrane Risk of Bias Tool and PEDro scale.
Twenty-six RCTs were included in the qualitative analysis and sixteen in the meta-analysis. There were no significant differences in PPTs between tDCS and sham, but differences were observed when applying tDCS over S1 in PPTs compared to sham. Significant differences in CPTs were observed between tDCS and sham over DLPFC and differences in pain intensity were observed between tDCS and sham over M1. Non-significant effects were found for the effects of tDCS on HPTs.
tDCS anodic over S1 stimulation increases PPTs, while a-tDCS over DLPFC affects CPTs. The HPTs with tDCS are worse. Finally, M1 a-tDCS seems to reduce evoked pain intensity in healthy subjects.</description><identifier>ISSN: 2076-3425</identifier><identifier>EISSN: 2076-3425</identifier><identifier>DOI: 10.3390/brainsci14010009</identifier><identifier>PMID: 38275514</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Agreements ; Bias ; central sensitization ; Clinical trials ; Electrical stimulation of the brain ; ESB ; Handbooks ; healthy subjects ; Meta-analysis ; Pain ; pain management ; Pain perception ; Systematic review ; transcranial direct current stimulation</subject><ispartof>Brain sciences, 2024-01, Vol.14 (1), p.9</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-a6a87a39b5514c7c128107bcaa533f630e9a6ced055c5507694a887bf6fdbb2e3</citedby><cites>FETCH-LOGICAL-c435t-a6a87a39b5514c7c128107bcaa533f630e9a6ced055c5507694a887bf6fdbb2e3</cites><orcidid>0000-0002-4791-6513 ; 0000-0003-2654-501X ; 0000-0001-9382-3855 ; 0000-0002-5542-4105 ; 0000-0002-1314-624X ; 0000-0003-1362-6312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2918567046/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918567046?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25752,27923,27924,37011,37012,44589,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38275514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gurdiel-Álvarez, Francisco</creatorcontrib><creatorcontrib>González-Zamorano, Yeray</creatorcontrib><creatorcontrib>Lerma-Lara, Sergio</creatorcontrib><creatorcontrib>Gómez-Soriano, Julio</creatorcontrib><creatorcontrib>Sánchez-González, Juan Luis</creatorcontrib><creatorcontrib>Fernández-Carnero, Josué</creatorcontrib><creatorcontrib>Navarro-López, Víctor</creatorcontrib><title>Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis</title><title>Brain sciences</title><addtitle>Brain Sci</addtitle><description>The aim of this study is to determine the effect that different tDCS protocols have on pain processing in healthy people, assessed using quantitative sensory tests (QST) and evoked pain intensity.
We systematically searched in EMBASE, CINAHL, PubMed, PEDro, PsycInfo, and Web of Science. Articles on tDCS on a healthy population and regarding QST, such as pressure pain thresholds (PPT), heat pain thresholds (HPT), cold pain threshold (CPT), or evoked pain intensity were selected. Quality was analyzed using the Cochrane Risk of Bias Tool and PEDro scale.
Twenty-six RCTs were included in the qualitative analysis and sixteen in the meta-analysis. There were no significant differences in PPTs between tDCS and sham, but differences were observed when applying tDCS over S1 in PPTs compared to sham. Significant differences in CPTs were observed between tDCS and sham over DLPFC and differences in pain intensity were observed between tDCS and sham over M1. Non-significant effects were found for the effects of tDCS on HPTs.
tDCS anodic over S1 stimulation increases PPTs, while a-tDCS over DLPFC affects CPTs. The HPTs with tDCS are worse. Finally, M1 a-tDCS seems to reduce evoked pain intensity in healthy subjects.</description><subject>Agreements</subject><subject>Bias</subject><subject>central sensitization</subject><subject>Clinical trials</subject><subject>Electrical stimulation of the brain</subject><subject>ESB</subject><subject>Handbooks</subject><subject>healthy subjects</subject><subject>Meta-analysis</subject><subject>Pain</subject><subject>pain management</subject><subject>Pain perception</subject><subject>Systematic review</subject><subject>transcranial direct current stimulation</subject><issn>2076-3425</issn><issn>2076-3425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkktv1DAQgCMEolXpnROyxGV7CPgR58FttS1tpfIoWc7RxJkUr7L2YjtF-Vv8wjq7pUK92Nb4m08zo0mSt4x-EKKiH1sH2nilWUYZpbR6kRxzWuSpyLh8-d_7KDn1fhMJWlIqJH2dHImSF1Ky7Dj5u3YQJfHQMJBz7VAFshqdQxNIHfR2HCBoa8ginK_qM3LR95HwJEZuRzBBh_h9j6RG462byBp90OaOLG7r9RkB05GvVmmFuz313VmF3s-ANuQKYQi_JlKP7WaWfiJLUk8-4DY6FfmB9xr_7B1fMEC6NDBMXvs3yaseBo-nj_dJ8vPzxXp1ld58u7xeLW9SlQkZUsihLEBU7dyoKhTjJaNFqwCkEH0uKFaQK-yolErKOKwqg7Is2j7vu7blKE6S64O3s7Bpdk5vwU2NBd3sA9bdNeBioQM2KLtclrIQKPqs4lXLgQsmOFasKzKhomtxcO2c_T3GGTVb7RUOAxi0o294TKJVnss8ou-foRs7utj7TLFS5gXNZooeKOWs9w77pwIZbeb1aJ6vR0x59yge2y12Twn_lkE8AAjUt-s</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Gurdiel-Álvarez, Francisco</creator><creator>González-Zamorano, Yeray</creator><creator>Lerma-Lara, Sergio</creator><creator>Gómez-Soriano, Julio</creator><creator>Sánchez-González, Juan Luis</creator><creator>Fernández-Carnero, Josué</creator><creator>Navarro-López, Víctor</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4791-6513</orcidid><orcidid>https://orcid.org/0000-0003-2654-501X</orcidid><orcidid>https://orcid.org/0000-0001-9382-3855</orcidid><orcidid>https://orcid.org/0000-0002-5542-4105</orcidid><orcidid>https://orcid.org/0000-0002-1314-624X</orcidid><orcidid>https://orcid.org/0000-0003-1362-6312</orcidid></search><sort><creationdate>20240101</creationdate><title>Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis</title><author>Gurdiel-Álvarez, Francisco ; González-Zamorano, Yeray ; Lerma-Lara, Sergio ; Gómez-Soriano, Julio ; Sánchez-González, Juan Luis ; Fernández-Carnero, Josué ; Navarro-López, Víctor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-a6a87a39b5514c7c128107bcaa533f630e9a6ced055c5507694a887bf6fdbb2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Agreements</topic><topic>Bias</topic><topic>central sensitization</topic><topic>Clinical trials</topic><topic>Electrical stimulation of the brain</topic><topic>ESB</topic><topic>Handbooks</topic><topic>healthy subjects</topic><topic>Meta-analysis</topic><topic>Pain</topic><topic>pain management</topic><topic>Pain perception</topic><topic>Systematic review</topic><topic>transcranial direct current stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gurdiel-Álvarez, Francisco</creatorcontrib><creatorcontrib>González-Zamorano, Yeray</creatorcontrib><creatorcontrib>Lerma-Lara, Sergio</creatorcontrib><creatorcontrib>Gómez-Soriano, Julio</creatorcontrib><creatorcontrib>Sánchez-González, Juan Luis</creatorcontrib><creatorcontrib>Fernández-Carnero, Josué</creatorcontrib><creatorcontrib>Navarro-López, Víctor</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Brain sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gurdiel-Álvarez, Francisco</au><au>González-Zamorano, Yeray</au><au>Lerma-Lara, Sergio</au><au>Gómez-Soriano, Julio</au><au>Sánchez-González, Juan Luis</au><au>Fernández-Carnero, Josué</au><au>Navarro-López, Víctor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis</atitle><jtitle>Brain sciences</jtitle><addtitle>Brain Sci</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>9</spage><pages>9-</pages><issn>2076-3425</issn><eissn>2076-3425</eissn><abstract>The aim of this study is to determine the effect that different tDCS protocols have on pain processing in healthy people, assessed using quantitative sensory tests (QST) and evoked pain intensity.
We systematically searched in EMBASE, CINAHL, PubMed, PEDro, PsycInfo, and Web of Science. Articles on tDCS on a healthy population and regarding QST, such as pressure pain thresholds (PPT), heat pain thresholds (HPT), cold pain threshold (CPT), or evoked pain intensity were selected. Quality was analyzed using the Cochrane Risk of Bias Tool and PEDro scale.
Twenty-six RCTs were included in the qualitative analysis and sixteen in the meta-analysis. There were no significant differences in PPTs between tDCS and sham, but differences were observed when applying tDCS over S1 in PPTs compared to sham. Significant differences in CPTs were observed between tDCS and sham over DLPFC and differences in pain intensity were observed between tDCS and sham over M1. Non-significant effects were found for the effects of tDCS on HPTs.
tDCS anodic over S1 stimulation increases PPTs, while a-tDCS over DLPFC affects CPTs. The HPTs with tDCS are worse. Finally, M1 a-tDCS seems to reduce evoked pain intensity in healthy subjects.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38275514</pmid><doi>10.3390/brainsci14010009</doi><orcidid>https://orcid.org/0000-0002-4791-6513</orcidid><orcidid>https://orcid.org/0000-0003-2654-501X</orcidid><orcidid>https://orcid.org/0000-0001-9382-3855</orcidid><orcidid>https://orcid.org/0000-0002-5542-4105</orcidid><orcidid>https://orcid.org/0000-0002-1314-624X</orcidid><orcidid>https://orcid.org/0000-0003-1362-6312</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Agreements Bias central sensitization Clinical trials Electrical stimulation of the brain ESB Handbooks healthy subjects Meta-analysis Pain pain management Pain perception Systematic review transcranial direct current stimulation |
| title | Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis |
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