Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice

Previously, we found that three types of Tieguanyin tea (Tgy-Q, Tgy-N and Tgy-C) extracts could alleviate Alzheimer's disease (AD) in a mouse model among which Tgy-C was more effective. In this study, APP/PS1 transgenic mice were used to investigate the metabolomic changes in the feces of mice...

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Published in:Metabolites 2022-05, Vol.12 (5), p.466
Main Authors: Tu, Youying, Kang, Hyunuk, Kim, Eunhye, Yang, Jiangfan, He, Puming, Wu, Yuanyuan, Li, Bo, Liu, Xiaobo, Liu, Junsheng
Format: Article
Language:English
Subjects:
ABC transporters
Alzheimer's disease
Amino acids
Biosynthesis
Correlation analysis
Digestive system
Discriminant analysis
Feces
Gastrointestinal tract
gut microbiota
Intestinal microflora
Metabolism
Metabolites
Metabolomics
Microbiota
Morphology
Mutation
Neurodegenerative diseases
oolong
Presenilin 1
Protein biosynthesis
Proteins
Quality control
rRNA 16S
Tea
Tieguanyin
Transgenic mice
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Summary:Previously, we found that three types of Tieguanyin tea (Tgy-Q, Tgy-N and Tgy-C) extracts could alleviate Alzheimer's disease (AD) in a mouse model among which Tgy-C was more effective. In this study, APP/PS1 transgenic mice were used to investigate the metabolomic changes in the feces of mice treated with Tieguanyin tea extracts. Results showed that the profile of fecal metabolites was obviously changed in AD mice. Metabolomics analysis found the effects of Tgy-C, especially its decreasing effect on the fecal metabolites in AD mice-132 of the 155 differential metabolites were decreased. KEGG enrichment revealed that differential metabolites could participate in functional pathways including protein digestion and absorption, biosynthesis of amino acids and ABC transporters. Further comparisons of the metabolites between groups showed that although Tgy-N and Tgy-Q exerted a decreasing effect on the fecal metabolites, Tgy-C was more effective. Moreover, correlation analysis found that the levels of the fecal metabolites were highly correlated with the contents of functional components in tea extracts. Finally, 16S rDNA sequencing presented that Tieguanyin extracts modified the gut microbiota by targeting diverse bacteria. In this study, we investigated the differences of three types of Tieguanyin tea extracts on the fecal metabolites as well as the bacterial community of the gut microbiota in AD mice. The identified differential metabolites and the changed intestinal bacteria might provide potential diagnostic biomarkers for the occurrence and progression of AD.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo12050466