How Stem and Progenitor Cells Can Affect Renal Diseases

Stem and progenitor cells have been observed to contribute to regenerative processes in acute renal failure and chronic kidney disease. Recent research has delved into the intricate mechanisms by which stem and progenitor cells exert their influence on kidney diseases. Understanding how these cells...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2024-08, Vol.13 (17), p.1460
Main Authors: Montenegro, Francesca, Giannuzzi, Francesca, Picerno, Angela, Cicirelli, Antonella, Stea, Emma Diletta, Di Leo, Vincenzo, Sallustio, Fabio
Format: Article
Language:English
Subjects:
Animals
Antineutrophil cytoplasmic antibodies
Basement membranes
Body fat
Bone marrow
C3 glomerulopathy
Cytokines
Diabetes mellitus
diabetic nephropathy
Glomerulonephritis
Homeostasis
Humans
IgA nephropathy
Immunoglobulin A
Immunomodulation
Kidney - pathology
Kidney diseases
Kidney Diseases - pathology
Kidney Diseases - therapy
Lupus nephritis
Lymphocytes
Membranous nephropathy
Progenitor cells
Regeneration
regenerative mechanisms
Renal failure
renal progenitors
Stem cells
Stem Cells - cytology
stem-cell transplant
Tissue engineering
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Summary:Stem and progenitor cells have been observed to contribute to regenerative processes in acute renal failure and chronic kidney disease. Recent research has delved into the intricate mechanisms by which stem and progenitor cells exert their influence on kidney diseases. Understanding how these cells integrate with the existing renal architecture and their response to injury could pave the way for innovative treatment strategies aimed at promoting kidney repair and regeneration. Overall, the role of stem and progenitor cells in kidney diseases is multifaceted, with their ability to contribute to tissue regeneration, immune modulation, and the maintenance of renal homeostasis. Here, we review the studies that we have available today about the involvement of stem and progenitor cells both in regenerative therapies and in the causes of renal diseases, as well as in natural healing mechanisms, taking into account the main kidney disorders, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, C3 glomerulopathy, focal segmental glomerulosclerosis, idiopathic membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and ANCA-associated crescentic glomerulonephritis. Moreover, based on the comprehensive data available in the framework of the specific kidney diseases on stem cells and renal progenitors, we hypothesize a possible role of adult renal progenitors in exacerbating or recovering the illness.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13171460