Amiodarone-induced bone marrow granulomas: an unusual cause of reversible pancytopenia

Bone marrow infiltration by granulomas rarely presents with cytopenias and is usually a result of atypical infections, lymphomas, or sarcoidosis. Drugs are also an important but often overlooked causal agent of bone marrow granulomas. Although rare, amiodarone has been associated with bone marrow gr...

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Bibliographic Details
Published in:Hematology reports 2010-09, Vol.2 (1), p.e6-e6
Main Authors: Erie, Andrew J, McClure, Rebecca F, Wolanskyj, Alexandra P
Format: Article
Language:English
Subjects:
Amiodarone
Bone growth
Bone marrow
Bone Marrow Granulomas
Case-Report
Granuloma
Granulomas
Lymphoma
Pancytopenia
Sarcoidosis
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Summary:Bone marrow infiltration by granulomas rarely presents with cytopenias and is usually a result of atypical infections, lymphomas, or sarcoidosis. Drugs are also an important but often overlooked causal agent of bone marrow granulomas. Although rare, amiodarone has been associated with bone marrow granuloma formation. This case report describes a 73-year-old male who presented with pancytopenia during a preoperative evaluation. Amiodarone therapy was suspected to be the causal agent after diagnostic evaluation and exclusion of other causes. After cessation of amiodarone, the patient's pancytopenia gradually resolved over a period of several months. Our report illustrates an often overlooked yet important cause of reversible pancytopenia owing to suspected amiodarone-induced bone marrow granuloma formation, and guides clinicians in an expected timeline for blood count improvement after cessation of this drug.
ISSN:2038-8330
2038-8322
2038-8330
DOI:10.4081/hr.2010.e6