Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterati...

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Bibliographic Details
Published in:Signal transduction and targeted therapy 2021-06, Vol.6 (1), p.245-245, Article 245
Main Authors: Zhu, Xudong, Chen, Zhiyang, Shen, Weiyan, Huang, Gang, Sedivy, John M., Wang, Hu, Ju, Zhenyu
Format: Article
Language:English
Subjects:
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692/308
Aging
Aging - genetics
Aging - metabolism
Cancer Research
Cell Biology
Cell Differentiation - genetics
Cellular Senescence - genetics
Epigenetics
Epigenomics
Humans
Inflammation - genetics
Inflammation - metabolism
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Pathology
Review
Review Article
Senescence
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Summary:Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.
ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-021-00646-9