Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications

One of the most significant classes of mycotoxins, aflatoxins (AFTs), can cause a variety of detrimental outcomes, including cancer, hepatitis, aberrant mutations, and reproductive issues. Among the 21 identified AFTs, aflatoxin B1 (AFB1) is the most harmful to humans and animals. The mechanisms of...

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Bibliographic Details
Published in:Antioxidants 2022-10, Vol.11 (10), p.2031
Main Authors: Dai, Chongshan, Tian, Erjie, Hao, Zhihui, Tang, Shusheng, Wang, Zhanhui, Sharma, Gaurav, Jiang, Haiyang, Shen, Jianzhong
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AFB1
Aflatoxin B1
Aflatoxins
AKT protein
Animals
Antioxidants
Apoptosis
Autophagy
Chronic illnesses
Curcumin
detoxification effects
Health aspects
Heavy metals
Hepatitis
Immunology
Immunoregulation
Inflammation
Kinases
Lipid peroxidation
Liver cancer
Mammalian cells
Metabolites
Mitochondria
molecular mechanisms
Molecular modelling
Natural products
Neurotoxicity
NF-κB protein
Oxidative stress
p53 Protein
Proteins
Reactive oxygen species
Review
TOR protein
Toxicity
Turmeric
Wnt protein
β-Catenin
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Summary:One of the most significant classes of mycotoxins, aflatoxins (AFTs), can cause a variety of detrimental outcomes, including cancer, hepatitis, aberrant mutations, and reproductive issues. Among the 21 identified AFTs, aflatoxin B1 (AFB1) is the most harmful to humans and animals. The mechanisms of AFB1-induced toxicity are connected to the generation of excess reactive oxygen species (ROS), upregulation of CYP450 activities, oxidative stress, lipid peroxidation, apoptosis, mitochondrial dysfunction, autophagy, necrosis, and inflammatory response. Several signaling pathways, including p53, PI3K/Akt/mTOR, Nrf2/ARE, NF-κB, NLRP3, MAPKs, and Wnt/β-catenin have been shown to contribute to AFB1-mediated toxic effects in mammalian cells. Curcumin, a natural product with multiple therapeutic activities (e.g., anti-inflammatory, antioxidant, anticancer, and immunoregulation activities), could revise AFB1-induced harmful effects by targeting these pathways. Therefore, the potential therapeutic use of curcumin against AFB1-related side effects and the underlying molecular mechanisms are summarized. This review, in our opinion, advances significant knowledge, sparks larger discussions, and drives additional improvements in the hazardous examination of AFTs and detoxifying the application of curcumin.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11102031