Drug discovery and computational strategies in the multitarget drugs era

The pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases. These computational studies have the advantage of being less expensive and optimize the study time, and thus the interest in this area is incre...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2018-01, Vol.54 (spe)
Main Authors: Viana, Jéssika de Oliveira, Félix, Mayara Barbalho, Maia, Mayara dos Santos, Serafim, Vanessa de Lima, Scotti, Luciana, Scotti, Marcus Tullius
Format: Article
Language:English
Subjects:
Diseases
Drug design
Drugs
Flexibility
Households
In silico
Kinases
Multitarget compounds
Parasites
Parasitic diseases
Pharmaceutical industry
PHARMACOLOGY & PHARMACY
R&D
Research & development
Tropical diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases. These computational studies have the advantage of being less expensive and optimize the study time, and thus the interest in this area is increasing. Among the techniques used is the development of multitarget directed ligands (MTDLs), which has become an ascending technique, mainly due to the improvement in the quality of treatment involving several drugs. Multitarget therapy is more effective than traditional drug therapy that emphasizes maximum selectivity for a single target. In this review a multitarget drug survey was carried out as a promising strategy in several important diseases: neglected diseases, neurodegenerative diseases, AIDS, and cancer. In addition, we discuss Computer-Aided Drug Design (CADD) techniques as a tool in the projection of multitarget compounds against these diseases.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902018000001010