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Factors associated with door-in to door-out delays among ST-segment elevation myocardial infarction (STEMI) patients transferred for primary percutaneous coronary intervention: a population-based cohort study in Ontario, Canada

Compared to ST-segment elevation myocardial infarction (STEMI) patients who present at centres with catheterization facilities, those transferred for primary percutaneous coronary intervention (PCI) have substantially longer door-in to door-out (DIDO) times, where DIDO is defined as the time interva...

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Published in:BMC cardiovascular disorders 2018-10, Vol.18 (1), p.204-204, Article 204
Main Authors: Shi, Oumin, Khan, Anam M, Rezai, Mohammad R, Jackevicius, Cynthia A, Cox, Jafna, Atzema, Clare L, Ko, Dennis T, Stukel, Thérèse A, Lambert, Laurie J, Natarajan, Madhu K, Zheng, Zhi-Jie, Tu, Jack V
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cites cdi_FETCH-LOGICAL-c423t-f89a6ed3e02346d61af87e1d74772dfaeecdd5a83076890949c618f9e74e1b983
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container_title BMC cardiovascular disorders
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creator Shi, Oumin
Khan, Anam M
Rezai, Mohammad R
Jackevicius, Cynthia A
Cox, Jafna
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Ko, Dennis T
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Lambert, Laurie J
Natarajan, Madhu K
Zheng, Zhi-Jie
Tu, Jack V
description Compared to ST-segment elevation myocardial infarction (STEMI) patients who present at centres with catheterization facilities, those transferred for primary percutaneous coronary intervention (PCI) have substantially longer door-in to door-out (DIDO) times, where DIDO is defined as the time interval from arrival at a non-PCI hospital, to transfer to a PCI hospital. We aimed to identify potentially modifiable factors to improve DIDO times in Ontario, Canada and to assess the impact of DIDO times on 30-day mortality. A population-based, retrospective cohort study of 966 STEMI patients transferred for primary PCI in Ontario in 2012 was conducted. Baseline factors were examined across timely DIDO status. Multivariate logistic regression was used to examine independent predictors of timely DIDO as well as the association between DIDO times and 30-day mortality. The median DIDO time was 55 min, with 20.1% of patients achieving the recommended DIDO benchmark of ≤30 min. Age (OR 0.30, 95% CI: 0.16-0.56), symptom-to-first medical contact (FMC) time (OR 0.60, 95% CI: 0.39-0.90; OR 0.53, 95% CI:0.35-0.81) and emergency medical services transport with a pre-hospital electrocardiogram (ECG) (OR 2.63, 95% CI:1.59-4.35) were the strongest predictors of timely DIDO. Patients with timely ECG were more likely to have recommended DIDO times (33.0% vs 12.3%; P 
doi_str_mv 10.1186/s12872-018-0940-z
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We aimed to identify potentially modifiable factors to improve DIDO times in Ontario, Canada and to assess the impact of DIDO times on 30-day mortality. A population-based, retrospective cohort study of 966 STEMI patients transferred for primary PCI in Ontario in 2012 was conducted. Baseline factors were examined across timely DIDO status. Multivariate logistic regression was used to examine independent predictors of timely DIDO as well as the association between DIDO times and 30-day mortality. The median DIDO time was 55 min, with 20.1% of patients achieving the recommended DIDO benchmark of ≤30 min. Age (OR 0.30, 95% CI: 0.16-0.56), symptom-to-first medical contact (FMC) time (OR 0.60, 95% CI: 0.39-0.90; OR 0.53, 95% CI:0.35-0.81) and emergency medical services transport with a pre-hospital electrocardiogram (ECG) (OR 2.63, 95% CI:1.59-4.35) were the strongest predictors of timely DIDO. Patients with timely ECG were more likely to have recommended DIDO times (33.0% vs 12.3%; P &lt; 0.001). A significantly higher proportion of those who met the DIDO benchmark had timely FMC-to-balloon times (78.7% vs 27.4%; P &lt; 0.001). Compared to patients with DIDO time ≤ 30 min, those with DIDO times &gt; 90 min had significantly higher adjusted 30-day mortality rates (OR 2.82, 95% CI:1.10-7.19). While benchmark DIDO times were still rarely achieved in the province, we identified several potentially modifiable factors in the STEMI system that might be targeted to improve DIDO times. 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Khan, Anam M ; Rezai, Mohammad R ; Jackevicius, Cynthia A ; Cox, Jafna ; Atzema, Clare L ; Ko, Dennis T ; Stukel, Thérèse A ; Lambert, Laurie J ; Natarajan, Madhu K ; Zheng, Zhi-Jie ; Tu, Jack V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-f89a6ed3e02346d61af87e1d74772dfaeecdd5a83076890949c618f9e74e1b983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Ambulatory care</topic><topic>Angioplasty</topic><topic>Balloon treatment</topic><topic>Benchmarking</topic><topic>Catheterization</topic><topic>Cohort analysis</topic><topic>Databases, Factual</topic><topic>Door-in to door-out (DIDO)</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Emergency Medical Services</topic><topic>Emergency services</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Ontario</topic><topic>Patient Transfer</topic><topic>Patients</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Pre-hospital electrocardiogram (ECG)</topic><topic>Primary percutaneous coronary intervention (PCI)</topic><topic>Privacy</topic><topic>Quality Improvement</topic><topic>Quality Indicators, Health Care</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>ST Elevation Myocardial Infarction - diagnostic imaging</topic><topic>ST Elevation Myocardial Infarction - mortality</topic><topic>ST Elevation Myocardial Infarction - surgery</topic><topic>ST-segment elevation myocardial infarction (STEMI)</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Time-to-Treatment</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Oumin</creatorcontrib><creatorcontrib>Khan, Anam M</creatorcontrib><creatorcontrib>Rezai, Mohammad R</creatorcontrib><creatorcontrib>Jackevicius, Cynthia A</creatorcontrib><creatorcontrib>Cox, Jafna</creatorcontrib><creatorcontrib>Atzema, Clare L</creatorcontrib><creatorcontrib>Ko, Dennis T</creatorcontrib><creatorcontrib>Stukel, Thérèse A</creatorcontrib><creatorcontrib>Lambert, Laurie J</creatorcontrib><creatorcontrib>Natarajan, Madhu K</creatorcontrib><creatorcontrib>Zheng, Zhi-Jie</creatorcontrib><creatorcontrib>Tu, Jack V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; 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We aimed to identify potentially modifiable factors to improve DIDO times in Ontario, Canada and to assess the impact of DIDO times on 30-day mortality. A population-based, retrospective cohort study of 966 STEMI patients transferred for primary PCI in Ontario in 2012 was conducted. Baseline factors were examined across timely DIDO status. Multivariate logistic regression was used to examine independent predictors of timely DIDO as well as the association between DIDO times and 30-day mortality. The median DIDO time was 55 min, with 20.1% of patients achieving the recommended DIDO benchmark of ≤30 min. Age (OR 0.30, 95% CI: 0.16-0.56), symptom-to-first medical contact (FMC) time (OR 0.60, 95% CI: 0.39-0.90; OR 0.53, 95% CI:0.35-0.81) and emergency medical services transport with a pre-hospital electrocardiogram (ECG) (OR 2.63, 95% CI:1.59-4.35) were the strongest predictors of timely DIDO. Patients with timely ECG were more likely to have recommended DIDO times (33.0% vs 12.3%; P &lt; 0.001). A significantly higher proportion of those who met the DIDO benchmark had timely FMC-to-balloon times (78.7% vs 27.4%; P &lt; 0.001). Compared to patients with DIDO time ≤ 30 min, those with DIDO times &gt; 90 min had significantly higher adjusted 30-day mortality rates (OR 2.82, 95% CI:1.10-7.19). While benchmark DIDO times were still rarely achieved in the province, we identified several potentially modifiable factors in the STEMI system that might be targeted to improve DIDO times. 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source Open Access: PubMed Central; Publicly Available Content (ProQuest)
subjects Adolescent
Adult
Age Factors
Aged
Ambulatory care
Angioplasty
Balloon treatment
Benchmarking
Catheterization
Cohort analysis
Databases, Factual
Door-in to door-out (DIDO)
EKG
Electrocardiography
Emergency Medical Services
Emergency services
Female
Heart attacks
Hospitals
Humans
Male
Middle Aged
Mortality
Myocardial infarction
Ontario
Patient Transfer
Patients
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - mortality
Population
Population studies
Population-based studies
Pre-hospital electrocardiogram (ECG)
Primary percutaneous coronary intervention (PCI)
Privacy
Quality Improvement
Quality Indicators, Health Care
Retrospective Studies
Risk Factors
ST Elevation Myocardial Infarction - diagnostic imaging
ST Elevation Myocardial Infarction - mortality
ST Elevation Myocardial Infarction - surgery
ST-segment elevation myocardial infarction (STEMI)
Studies
Time Factors
Time-to-Treatment
Treatment Outcome
Young Adult
title Factors associated with door-in to door-out delays among ST-segment elevation myocardial infarction (STEMI) patients transferred for primary percutaneous coronary intervention: a population-based cohort study in Ontario, Canada
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