Low serum iron is associated with anemia in CKD stage 1–4 patients with normal transferrin saturations

Low transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency. Because malnutrition and inflammation are associated with low TIBC in chronic kidney disease (CKD), TSAT might not reflect iron status or risk for anemia. We examined...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.8343-8343, Article 8343
Main Authors: Yu, Pei-Hua, Lin, Ming-Yen, Chiu, Yi-Wen, Lee, Jia-Jung, Hwang, Shang-Jyh, Hung, Chi-Chih, Chen, Hung-Chun
Format: Article
Language:English
Subjects:
692/308
692/4022
Anemia
C-reactive protein
Hemoglobin
Humanities and Social Sciences
Iron
Iron deficiency
Kidney diseases
Malnutrition
multidisciplinary
Nutrient deficiency
Risk factors
Science
Science (multidisciplinary)
Transferrins
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Summary:Low transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency. Because malnutrition and inflammation are associated with low TIBC in chronic kidney disease (CKD), TSAT might not reflect iron status or risk for anemia. We examined whether low serum iron was a risk factor for anemia in CKD patients with normal TSAT. Thus we compare the risk for anemia in 2500 CKD stage 1–4 patients divided by TSAT (cutoff: 20%) and serum iron (cutoff: 70 μg/dL in men, 60 μg/dL in women). Our results confirmed low TIBC (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-87401-w