Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer’s disease

ObjectivesGlutathione S-transferase alpha (GSTα) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases. The alterations in GSTα protein levels associated with Alzheimer’s disease and their impact on cognitive abilities remain unclear. Thus...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2024-12, Vol.16
Main Authors: Yangyang Tang, Ni Li, Linyan Dai, Xingsheng Wang, Xia Lai
Format: Article
Language:English
Subjects:
Alzheimer’s disease
blood markers
GSTα
MCI (mild cognitive impairment)
mild cognitive impairment
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Summary:ObjectivesGlutathione S-transferase alpha (GSTα) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases. The alterations in GSTα protein levels associated with Alzheimer’s disease and their impact on cognitive abilities remain unclear. Thus, investigating the fluctuations of GSTα protein levels in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is essential.MethodsDATA were enrolled from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, and we studied healthy individuals (as controls, a total of 54), patients with mild cognitive impairment (345), and patients with Alzheimer’s disease (96) A one-year follow-up was conducted to collect data on the dynamic changes of GSTα protein levels in plasma and primary information data, and to analyze the correlation between the changes in GSTα protein levels before and after the follow-up and cognitive function and its predictive value.ResultsPlasma GSTα protein levels were significantly lower in the AD group than in the CN group (0.94 vs1.05, p = 0.04) and the MCI group (0.94 vs1.09, p 
ISSN:1663-4365
DOI:10.3389/fnagi.2024.1517613