Plasma omega-3 PUFA and white matter mediated executive decline in older adults

Cross-sectional studies have identified long chain omega-3 polyunsaturated fatty acids (eicosapentaenoic acid 20:5n-3 and docosahexaenoic acid 22:6n-3 (O3PUFA) in association with fewer white matter lesions and better executive function in older adults. We hypothesized that O3PUFA are associated wit...

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Published in:Frontiers in aging neuroscience 2013, Vol.5, p.92-92
Main Authors: Bowman, Gene L, Dodge, Hiroko H, Mattek, Nora, Barbey, Aron K, Silbert, Lisa C, Shinto, Lynne, Howieson, Diane B, Kaye, Jeffrey A, Quinn, Joseph F
Format: Article
Language:English
Subjects:
Age
Aging
Alzheimer's disease
Apolipoprotein E4
Biomarkers
Blood
Cognition & reasoning
Cognitive ability
cognitive decline
Dementia
Diabetes
Docosahexaenoic acid
Eicosapentaenoic acid
Elderly
Executive Function
Fatty acids
Hypertension
Lipid Metabolism
longitudinal data analysis
Magnetic resonance imaging
MRI
Neurology
Neuroscience
Older people
Plasma
Polyunsaturated fatty acids
Substantia alba
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cited_by cdi_FETCH-LOGICAL-c556t-b7f5ce425568e80b7b3d7d45d1f8b0dd5e69be78c6d9c0f0737da2c248c98dfe3
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container_title Frontiers in aging neuroscience
container_volume 5
creator Bowman, Gene L
Dodge, Hiroko H
Mattek, Nora
Barbey, Aron K
Silbert, Lisa C
Shinto, Lynne
Howieson, Diane B
Kaye, Jeffrey A
Quinn, Joseph F
description Cross-sectional studies have identified long chain omega-3 polyunsaturated fatty acids (eicosapentaenoic acid 20:5n-3 and docosahexaenoic acid 22:6n-3 (O3PUFA) in association with fewer white matter lesions and better executive function in older adults. We hypothesized that O3PUFA are associated with less executive decline over time and that total white matter hyperintensity volume (WMH) mediates this association. Eighty-six non-demented older adults were followed over 4 years after measurement of plasma O3PUFA with annual evaluations of cognitive function. A subset of these participants also had brain MRI of total WMH available to conduct a formal mediation analysis of a putative relationship between O3PUFA and cognitive function. Mean age at baseline was 86, 62% were female and 11% carried the APOE4 allele. Each 100 μg/ml increase in plasma O3PUFA associated with 4 s less change in executive decline per year of aging (p = 0.02, fully adjusted model). O3PUFA was not associated with verbal memory or global cognitive changes. The significance of the association between O3PUFA and better executive function was lost once WMH was added to the regression model. Executive decline with age appears to be a cognitive domain particularly sensitive to plasma O3PUFA in longitudinal examination. O3PUFA may modulate executive functioning by mechanisms underlying the development of WMH, a biologically plausible hypothesis that warrants further investigation.
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subjects Age
Aging
Alzheimer's disease
Apolipoprotein E4
Biomarkers
Blood
Cognition & reasoning
Cognitive ability
cognitive decline
Dementia
Diabetes
Docosahexaenoic acid
Eicosapentaenoic acid
Elderly
Executive Function
Fatty acids
Hypertension
Lipid Metabolism
longitudinal data analysis
Magnetic resonance imaging
MRI
Neurology
Neuroscience
Older people
Plasma
Polyunsaturated fatty acids
Substantia alba
title Plasma omega-3 PUFA and white matter mediated executive decline in older adults
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