Nickel(II) N-Heterocyclic Carbene Complex for the Hydrogenation of 2-Acetylpyridine under Mild Conditions

Catalyst-mediated hydrogenation of ketones via hydride transfer can be directly used in the synthesis of alcohols which can exhibit great potential in the practical synthesis of pharmaceuticals. The application of Ni-NHC complexes in the hydrogenation of ketones is still limited. In a pursuit to stu...

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Bibliographic Details
Published in:Inorganics 2023-03, Vol.11 (3), p.120
Main Authors: Sharma, Mitu, Perkins, Amanda M., Duckworth, Alison K., Rouse, Emily J., Donnadieu, Bruno, Adhikari, Bhupendra, Stokes, Sean L., Emerson, Joseph P.
Format: Article
Language:English
Subjects:
2-acetylpyridine
Alcohol
Alcohols
Benzimidazoles
By products
Catalysis
Catalysts
Crystallography
Geometry
Hydrogenation
Ketones
Ligands
N-heterocyclic carbene (NHC)
Nickel
nickel(II)-NHC complex
NMR
Nuclear magnetic resonance
Synthesis
X-ray crystallography
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Summary:Catalyst-mediated hydrogenation of ketones via hydride transfer can be directly used in the synthesis of alcohols which can exhibit great potential in the practical synthesis of pharmaceuticals. The application of Ni-NHC complexes in the hydrogenation of ketones is still limited. In a pursuit to study the effect of Ni-NHC-based complexes in the reactivity towards hydrogenation, we have studied the catalytic efficiency of a pendent-type nickel complex [Ni(NHC)2](PF6)2 constructed from a benzimidazole moiety. The hydrogenation of 2-acetylpyridine was studied with respect to catalyst loading, reaction temperature, reaction time, and solvent medium. The complex was broadly characterized by X-ray crystallography, ESI-MS, NMR, UV-Vis, and IR spectral studies.
ISSN:2304-6740
2304-6740
DOI:10.3390/inorganics11030120