Evaluation of Demographic, Clinical, and Histological Characteristics of Spitz Nevus Among Iranian Patients: A Retrospective Study From 2016 to 2021

ABSTRACT Background and Aims Spitz nevus is a rare benign tumor classified among unusual melanocytic nevi. This study aimed to identify the demographic, clinical, and histopathological characteristics of Spitz nevus among Iranian patients. Methods This descriptive, retrospective study involved revie...

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Bibliographic Details
Published in:Health science reports 2024-12, Vol.7 (12), p.e70274-n/a
Main Authors: Aryanian, Zeinab, Kamyab, Kambiz, Shakoei, Safoura, Etesami, Ifa, Azhari, Vahidehsadat, Hesami, Sami, Khayyat, Azadeh, Hatami, Parvaneh
Format: Article
Language:English
Subjects:
Age
Biopsy
clinical
demographics
Disease
Gender
Histopathology
Hospitals
Hypotheses
Illnesses
Melanoma
Original Research
Pathology
Patients
Skin cancer
Spitz nevus
Tumors
Variables
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Summary:ABSTRACT Background and Aims Spitz nevus is a rare benign tumor classified among unusual melanocytic nevi. This study aimed to identify the demographic, clinical, and histopathological characteristics of Spitz nevus among Iranian patients. Methods This descriptive, retrospective study involved reviewing the records of patients diagnosed with Spitz nevus at a referral and academic hospital in Iran between 2016 and 2021. Data were extracted regarding demographic characteristics, including age, gender, location, clinical symptoms, disease duration, medical history, and medication history. Additionally, biopsied lesions were evaluated for histopathological features. Results A total of 86 patients were evaluated, comprising 37 males (43.5%) and 49 females (55.5%). The mean age was 15.6 years (SD ± 14.8). The most common sites of involvement were the upper extremities (23.3%) and face (17.4%). Disease durations of 1 and 2 years were the most prevalent, observed in 24 (27.9%) and 26 patients (30.2%), respectively. Notably, none of the patients had any underlying diseases. Histopathological evaluation revealed compound Spitz nevus in 25 patients (29.4%), junctional Spitz nevus in 14 patients (16.5%), and dermal Spitz nevus in 10 patients (11.8%). Conclusion This study provides a comprehensive overview of the demographics, clinical presentation, and histopathological features of Spitz nevus among Iranian patients, highlighting the necessity for ongoing research and innovation in diagnostic techniques.
ISSN:2398-8835
2398-8835
DOI:10.1002/hsr2.70274