GDF15 and Growth Control

Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor β (TGF-β) superfamily and is widely expressed in multiple mammalian tissues. Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum...

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Bibliographic Details
Published in:Frontiers in physiology 2018-11, Vol.9, p.1712-1712
Main Authors: Emmerson, Paul J, Duffin, Kevin L, Chintharlapalli, Sudhakar, Wu, Xinle
Format: Article
Language:English
Subjects:
cancer
GDF15
GFRAL
metabolic
obesity
Physiology
TGFβ
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Summary:Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor β (TGF-β) superfamily and is widely expressed in multiple mammalian tissues. Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum levels have a strong association with many diseases, including inflammation, cancer, cardiovascular diseases, and obesity, and potentially serve as reliable predictor of disease progression. A functional role for GDF15 has been suggested in cancer, cardiovascular disease, kidney disease and metabolic disease. However, the knowledge of its pathophysiological function at the molecular level is still limited and requires more investigation. Recent identification of the endogenous receptor for GDF15 may provide additional insight in to its' molecular mechanisms and relationship to disease states.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2018.01712