AA amyloid in human food chain is a possible biohazard

AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.21069-5, Article 21069
Main Authors: Rising, Anna, Gherardi, Paola, Chen, Gefei, Johansson, Jan, Oskarsson, Marie E., Westermark, Gunilla T., Westermark, Per
Format: Article
Language:English
Subjects:
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Alzheimer's disease
Amyloid beta-Peptides - analysis
Amyloid beta-Peptides - metabolism
Amyloidosis
Amyloidosis - prevention & control
Animals
Biochemistry and Molecular Biology
Biohazards
Biokemi och molekylärbiologi
Cattle
Fibrils
Food Chain
Food chains
Food Safety
Hazardous Substances - analysis
Hazardous Substances - metabolism
Humanities and Social Sciences
Humans
Italy
Meat
Medicin och hälsovetenskap
multidisciplinary
Neurodegenerative diseases
Neurosciences
Neurovetenskaper
Protein seeding
Red Meat - analysis
Science
Science (multidisciplinary)
Seeds
Serum Amyloid A Protein
Sweden
β-Amyloid
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Summary:AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid β peptide, associated with Alzheimer’s disease.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-00588-w