The retrovirus RNA trafficking granule: from birth to maturity

Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until...

Full description

Saved in:
Bibliographic Details
Published in:Retrovirology 2006-03, Vol.3 (1), p.18-18, Article 18
Main Authors: Cochrane, Alan W, McNally, Mark T, Mouland, Andrew J
Format: Article
Language:English
Subjects:
Alternative Splicing
Animals
Cell Nucleus - virology
Cytoplasm - virology
Humans
Retroviridae - genetics
Retroviridae - growth & development
Review
RNA Processing, Post-Transcriptional
RNA Transport
RNA, Messenger - genetics
RNA, Viral - genetics
Viral Proteins - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until the RNA reaches its final destination. For retroviral genomic RNA, the final destination is the capsid. Numerous studies have provided crucial information about these processes and serve as the basis for studies on the intracellular fate of retroviral RNA. Retroviral RNAs are like cellular mRNAs but their processing is more tightly regulated by multiple cis-acting sequences and the activities of many trans-acting proteins. This review describes the viral and cellular partners that retroviral RNA encounters during its maturation that begins in the nucleus, focusing on important events including splicing, 3' end-processing, RNA trafficking from the nucleus to the cytoplasm and finally, mechanisms that lead to its compartmentalization into progeny virions.
ISSN:1742-4690
1742-4690
DOI:10.1186/1742-4690-3-18