Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suita...

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Bibliographic Details
Published in:Gels 2024-02, Vol.10 (2), p.114
Main Authors: Zhou, Zhuxing, Wang, Jiajie, Jiang, Chaoqian, Xu, Kaiwang, Xu, Tengjing, Yu, Xinning, Fang, Jinghua, Yang, Yanyu, Dai, Xuesong
Format: Article
Language:English
Subjects:
Additives
Amino acids
Biocompatibility
Biological products
biomaterial
Biomedical materials
Blood vessels
Cartilage
Collagen
Crosslinked polymers
Crosslinking
Extracellular matrix
Functional materials
Growth factors
Health aspects
Hyaluronic acid
hydrogel
Hydrogels
Injuries
Knee
Mechanical properties
meniscus
Regeneration
repair
Surgical implants
Surgical techniques
Synthetic products
therapeutic effect
Tissue engineering
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Summary:Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suitable microenvironment. Additionally, hydrogels can be minimally invasively injected and can be adjusted to match the shape of the implant site. They can conveniently and effectively deliver bioactive additives and demonstrate good compatibility with other functional materials. These inherent qualities have made hydrogel a promising candidate for therapeutic approaches in meniscus repair and regeneration. This article provides a comprehensive review of the advancements made in the research on hydrogel application for meniscus tissue engineering. Firstly, the biomaterials and crosslinking strategies used in the formation of hydrogels are summarized and analyzed. Subsequently, the role of therapeutic additives, including cells, growth factors, and other active products, in facilitating meniscus repair and regeneration is thoroughly discussed. Furthermore, we summarize the key issues for designing hydrogels used in MTE. Finally, we conclude with the current challenges encountered by hydrogel applications and suggest potential solutions for addressing these challenges in the field of MTE. We hope this review provides a resource for researchers and practitioners interested in this field, thereby facilitating the exploration of new design possibilities.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels10020114