Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 63...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Ghabbour, Hazem A., Maklad, Yousreya A., El-Azzouny, Aida A., Aboul-Enein, Mohamed N., Attia, Mohamed I.
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - chemical synthesis
Anticonvulsants - chemistry
Anticonvulsants - pharmacology
Chemistry
Crystallography, X-Ray
Drug dosages
Epilepsy
Ethanol
Hydrazines - chemical synthesis
Hydrazines - chemistry
Hydrazines - pharmacology
Imidazoles - chemical synthesis
Imidazoles - chemistry
Imidazoles - pharmacology
Male
Mice
Neurotoxicity
Pharmaceuticals
Single crystals
Structure-Activity Relationship
Toxicology
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Summary:Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μmol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds 6a–p was confirmed via single crystal X-ray structure of compound 6g.
ISSN:2356-6140
1537-744X
DOI:10.1155/2014/357403