Acupuncture therapy in treating migraine: results of a magnetic resonance spectroscopy imaging study

Acupuncture has been proven to be effective as an alternative therapy in treating migraine, but the pathophysiological mechanisms of the treatment remain unclear. This study investigated possible neurochemical responses to acupuncture treatment. Proton magnetic resonance spectroscopy imaging was use...

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Bibliographic Details
Published in:Journal of pain research 2018-01, Vol.11, p.889-900
Main Authors: Gu, Tao, Lin, Lei, Jiang, Yun, Chen, Juan, D'Arcy, Ryan Cn, Chen, Min, Song, Xiaowei
Format: Article
Language:English
Subjects:
Acupuncture
Biochemistry
Chinese medicine
Headache
Health aspects
magnetic resonance spectroscopy imaging
Metabolites
Migraine
Nuclear magnetic resonance spectroscopy
Original Research
Spectroscopy
Systematic review
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Summary:Acupuncture has been proven to be effective as an alternative therapy in treating migraine, but the pathophysiological mechanisms of the treatment remain unclear. This study investigated possible neurochemical responses to acupuncture treatment. Proton magnetic resonance spectroscopy imaging was used to investigate biochemical levels pre- and post-acupuncture treatment. Participants (N=45) included subjects diagnosed with: 1) migraine without aura; 2) cervicogenic headache; and 3) healthy controls. Participants in the two patient groups received verum acupuncture using acupoints that target migraine without aura but not cervicogenic headache, while the healthy controls received a sham treatment. All participants had magnetic resonance spectroscopy scans before and after the acupuncture therapy. Levels of brain metabolites were examined in relation to clinical headache assessment scores. A significant increase in -acetylaspartate/creatine was observed in bilateral thalamus in migraine without aura after the acupuncture treatment, which was significantly correlated with the headache intensity score. The data demonstrate brain biochemical changes underlying the effect of acupuncture treatment of migraine.
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S162696