Inherited Cardiomyopathies and the Role of Mutations in Non-coding Regions of the Genome

Cardiomyopathies (CMs) are a group of cardiac pathologies caused by an intrinsic defect within the myocardium. The relative contribution of genetic mutations in the pathogenesis of certain CMs, such as hypertrophic cardiomyopathy (HCM), arrythmogenic right/left ventricular cardiomyopathy (ARVC) and...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2018-06, Vol.5, p.77-77
Main Authors: Salman, Oday F, El-Rayess, Hebah M, Abi Khalil, Charbel, Nemer, Georges, Refaat, Marwan M
Format: Article
Language:English
Subjects:
arrythmogenic cardiomyopathy
cardiomyopathy
Cardiovascular Medicine
dilated cardiomyopathy
hypertrophic cardiomyopathy
restrictive cardiomyopathy
spongiform cardiomyopathy
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Summary:Cardiomyopathies (CMs) are a group of cardiac pathologies caused by an intrinsic defect within the myocardium. The relative contribution of genetic mutations in the pathogenesis of certain CMs, such as hypertrophic cardiomyopathy (HCM), arrythmogenic right/left ventricular cardiomyopathy (ARVC) and left ventricular non-compacted cardiomyopathy (LVNC) has been established in comparison to dilated cardiomyopathy (DCM) and restrictive cardiomyopathy (RCM). The aim of this article is to review mutations in the non-coding parts of the genome, namely, microRNA, promoter elements, enhancer/silencer elements, 3'/5'UTRs and introns, that are involved in the pathogenesis CMs. Additionally, we will explore the role of some long non-coding RNAs in the pathogenesis of CMs.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2018.00077