Mammographic density parameters and breast cancer tumor characteristics among postmenopausal women

Mammographic density is an important breast cancer risk factor, although it is not clear whether the association differs across breast cancer tumor subtypes. We examined the association between indicators of mammographic density and breast cancer risk by tumor subtype among postmenopausal women by i...

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Bibliographic Details
Published in:Breast cancer targets and therapy 2019-08, Vol.11, p.261-271
Main Authors: Velásquez García, Héctor A, Gotay, Carolyn C, Wilson, Christine M, Lohrisch, Caroline A, Lai, Agnes S, Aronson, Kristan J, Spinelli, John J
Format: Article
Language:English
Subjects:
Bias
Breast cancer
Health aspects
Health risk assessment
heterogeneity
Hormone replacement therapy
Mammographic density
Mammography
multinomial logistic regression
Original Research
Post-menopause
Postmenopausal women
Risk factors
Studies
tumor characteristics
Tumors
Women
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Summary:Mammographic density is an important breast cancer risk factor, although it is not clear whether the association differs across breast cancer tumor subtypes. We examined the association between indicators of mammographic density and breast cancer risk by tumor subtype among postmenopausal women by investigating heterogeneity across tumor characteristics. Mammographic density measures were determined for 477 breast cancer cases and 588 controls, all postmenopausal, in Vancouver, British Columbia, using digitized screening mammograms and Cumulus software. Mammographic dense (DA), non-dense (NDA), and percent dense (PDA) areas were treated as continuous covariates and categorized into quartiles according to the distribution in controls. For cases only, tests for heterogeneity between tumor subtypes were assessed by multinomial logistic regression. Associations between mammographic density and breast cancer risk were modeled for each subtype separately through unconditional logistic regression. Heterogeneity was apparent for the association of PDA with tumor size ( -heterogeneity=0.04). Risk did not differ across the other assessed tumor characteristics ( -heterogeneity values >0.05). These findings do not provide strong evidence that mammographic density parameters differentially affect specific breast cancer tumor characteristics.
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S192766