The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice

Obesity is a worldwide public health problem whose prevalence rate has increased steadily over the last few years. Therefore, it is urgent to improve the management of obesity and its comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this regard, the present...

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Bibliographic Details
Published in:Antioxidants 2023-03, Vol.12 (4), p.832
Main Authors: Molina-Tijeras, Jose Alberto, Ruiz-Malagón, Antonio Jesús, Hidalgo-García, Laura, Diez-Echave, Patricia, Rodríguez-Sojo, María Jesús, Cádiz-Gurrea, María de la Luz, Segura-Carretero, Antonio, Del Palacio, José Pérez, González-Tejero, María Reyes, Rodríguez-Cabezas, María Elena, Gálvez, Julio, Rodríguez-Nogales, Alba, Vezza, Teresa, Algieri, Francesca
Format: Article
Language:English
Subjects:
Adipose tissue
Antioxidants
Body weight gain
Chronic illnesses
Comorbidity
Diabetes
Gas flow
Glucose tolerance
High fat diet
Inflammation
insulin resistance
Interleukin 6
Lavandula multifida
Lipid peroxidation
Macrophages
Mucin
Obesity
Oxidative stress
Permeability
Public health
Sodium
Solvents
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Summary:Obesity is a worldwide public health problem whose prevalence rate has increased steadily over the last few years. Therefore, it is urgent to improve the management of obesity and its comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this regard, the present study aimed to investigate a well-characterized extract of (LME) in an experimental model of obesity in mice and explore the underlying mechanisms. Interestingly, the daily administration of LME reduced weight gain as well as improved insulin sensitivity and glucose tolerance. Additionally, LME ameliorated the inflammatory state in both liver and adipose tissue by decreasing the expression of various proinflammatory mediators ( , , , , , , and ) and prevented increased gut permeability by regulating the expression of mucins ( , , and ) and proteins implicated in epithelial barrier integrity maintenance ( , , and ). In addition, LME showed the ability to reduce oxidative stress by inhibiting nitrite production on macrophages and lipid peroxidation. These results suggest that LME may represent a promising complementary approach for the management of obesity and its comorbidities.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12040832