Role of Proangiogenic Factors in Immunopathogenesis of Multiple Sclerosis

Angiogenesis is a complex and balanced process in which new blood vessels form from preexisting ones by sprouting, splitting, growth and remodeling. This phenomenon plays a vital role in many physiological and pathological processes. However, the disturbance in physiological process can play a role...

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Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2016-02, Vol.15 (1), p.1-12
Main Authors: Hamid, Kabir Magaji, Mirshafiey, Abbas
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis inducing agent
Angiogenic Proteins - immunology
Angiogenic Proteins - metabolism
Animal models
Animals
Blood vessels
Blood-brain barrier
Blood-Brain Barrier - immunology
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Central Nervous System - immunology
Central Nervous System - metabolism
Central Nervous System - pathology
Endothelial cells
Experimental autoimmune encephalomyelitis
Extracellular matrix
Humans
Immunopathogenesis
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Inflammatory diseases
Matrix metalloproteinase
Multiple sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - metabolism
Multiple Sclerosis - pathology
Neovascularization, Pathologic
Pathogenesis
Physiology
Signal Transduction
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Summary:Angiogenesis is a complex and balanced process in which new blood vessels form from preexisting ones by sprouting, splitting, growth and remodeling. This phenomenon plays a vital role in many physiological and pathological processes. However, the disturbance in physiological process can play a role in pathogenesis of some chronic inflammatory diseases, including multiple sclerosis (MS) in human and its animal model. Although the relation between abnormal blood vessels and MS lesions was established in previous studies, but the role of pathological angiogenesis remains unclear. In this study, the link between proangiogenic factors and multiple sclerosis pathogenesis was examined by conducting a systemic review. Thus we searched the English medical literature via PubMed, ISI web of knowledge, Medline and virtual health library (VHL) databases. In this review, we describe direct and indirect roles of some proangiogenic factors in MS pathogenesis and report the association of these factors with pathological and inflammatory angiogenesis.
ISSN:1735-1502
1735-5249