Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression

Chemotherapy is one of the most widely used treatments for breast cancer (BC). However, there is evidence of side effects like cognitive changes related to the chemotherapy treatment. The aim of the study was not only to summarize the existing evidence on the relationship between chemotherapy and co...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2023-01, Vol.56 (1), p.1-e12947
Main Authors: Oliveira, M.E.C, Torres, G.S.V, Franklin, R.G, Gomes, K.A.L, Nobrega, W.F.S, Fernandes, T.P, Santos, N.A
Format: Article
Language:English
Subjects:
BIOLOGY
Breast cancer
Cancer
Cancer therapies
Chemotherapy
Chemotherapy-related cognitive impairment
Cognition
Cognitive ability
Complications and side effects
Drug therapy
MEDICINE, RESEARCH & EXPERIMENTAL
Mental health
Meta-analysis
Neuroscience
Systematic Review
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Summary:Chemotherapy is one of the most widely used treatments for breast cancer (BC). However, there is evidence of side effects like cognitive changes related to the chemotherapy treatment. The aim of the study was not only to summarize the existing evidence on the relationship between chemotherapy and cognitive performance in women with BC but also to identify additional consequences and aspects associated with these impairments. We conducted a systematic review with meta-analysis and meta-regression to present updated information on the matter. We retrieved data from the databases PubMed, Web of Science, PsycINFO, CINAHL, and Scopus. Twenty studies comprising over 2,500 women were examined and the results indicated that chemotherapy can compromise cognition in women with BC (-1.10 OR [95%CI: -1.81 to -0.74], P
ISSN:0100-879X
1414-431X
1414-431X
1678-4510
DOI:10.1590/1414-431X2023e12947