Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome sequencing data published for 684 cases of >7 common tumor types and >35 breeds, with rigorous quality control and breed validation. Our res...

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Bibliographic Details
Published in:Nature communications 2021-08, Vol.12 (1), p.4670-4670, Article 4670
Main Authors: Alsaihati, Burair A., Ho, Kun-Lin, Watson, Joshua, Feng, Yuan, Wang, Tianfang, Dobbin, Kevin K., Zhao, Shaying
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
45
45/23
631/67/69
631/67/70
Animals
Biomarkers, Tumor - genetics
Biomedical materials
Bone cancer
Cancer
Databases, Genetic
Dog Diseases - genetics
Dogs
Gene sequencing
Genomics
Glioma
Humanities and Social Sciences
Humans
Mammary gland
Melanoma
multidisciplinary
Mutation
Neoplasms - classification
Neoplasms - genetics
Neoplasms - veterinary
Osteosarcoma
p53 Protein
Quality control
Reproducibility of Results
Science
Science (multidisciplinary)
Tumor Suppressor Protein p53 - genetics
Tumors
Whole Genome Sequencing
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Summary:Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome sequencing data published for 684 cases of >7 common tumor types and >35 breeds, with rigorous quality control and breed validation. Our results indicate that canine tumor alteration landscape is tumor type-dependent, but likely breed-independent. Each tumor type harbors major pathway alterations also found in its human counterpart (e.g., PI3K in mammary tumor and p53 in osteosarcoma). Mammary tumor and glioma have lower tumor mutational burden (TMB) (median 
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-24836-9