Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis

This study aimed to assess the prognostic value of red cell distribution width (RDW) RDW-to-calcium ratio (RDW/Ca), neutrophils-to-lymphocytes ratio (N/L), platelets-to-lymphocytes ratio (P/L) and other easy to obtain and inexpensive hematological and biochemical parameters in dogs with acute pancre...

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Bibliographic Details
Published in:Animals (Basel) 2022-12, Vol.12 (24), p.3483
Main Authors: Guglielmini, Carlo, Crisi, Paolo Emidio, Tardo, Antonio Maria, Di Maggio, Roberta, Contiero, Barbara, Boari, Andrea, Fracassi, Federico, Miglio, Arianna
Format: Article
Language:English
Subjects:
acute pancreatitis
Bilirubin
Biochemistry
Biomarkers
Blood
Blood platelets
Calcium
canine
Confidence intervals
Creatinine
Death
Disease
Hazard identification
Hematology
Investigations
Laboratories
laboratory biomarker
Leukocytes (neutrophilic)
Lymphocytes
Medical prognosis
Mortality
Neutrophils
Nitrogen
outcome
Pancreatitis
Proteins
RDW
RDW-to-total calcium ratio
Software
Statistical analysis
Survival
Triglycerides
Urea
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Summary:This study aimed to assess the prognostic value of red cell distribution width (RDW) RDW-to-calcium ratio (RDW/Ca), neutrophils-to-lymphocytes ratio (N/L), platelets-to-lymphocytes ratio (P/L) and other easy to obtain and inexpensive hematological and biochemical parameters in dogs with acute pancreatitis. This is a multicenter, retrospective cohort study including 70 client-owned dogs. The accuracy of clinical and laboratory variables to predict short-term death (i.e., dead by 14 days) was tested by calculating the area under the receiver-operating characteristic curve (AUC). Independent predictors of death were identified using the multivariable Cox proportional hazards regression model. The survival rate was 72.9% (51 dogs) and 19 dogs died within 14 days of admission from AP. RDW and blood urea nitrogen (BUN) had good accuracy to predict short-term dead with AUC of 0.74 and 0.70 at the cut-off of >12.7% and >42 mg/dL, respectively. According to the multivariable model, RDW (hazard ratio and 95% confidence interval [HR, 95% CI] = 5.08, 95% CI = 1.14−22.67; p = 0.03), BUN (HR = 1.00, 95% CI = 1.00−1.01; p < 0.01) and bilirubin (HR = 2.46, 95% CI = 1.38−4.39; p < 0.01) were independent predictors of death. The results indicate that RDW, BUN and bilirubin are useful predictors of short-term death in dogs with acute pancreatitis.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani12243483