The Influence of Mechanical Bowel Preparation on Volatile Organic Compounds for the Detection of Gastrointestinal Disease-A Systematic Review

(1) Background: Colorectal cancer is the second commonest cause of cancer deaths worldwide; recently, volatile organic compounds (VOCs) have been proposed as potential biomarkers of this disease. In this paper, we aim to identify and review the available literature on the influence of mechanical bow...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2023-01, Vol.23 (3), p.1377
Main Authors: Krishnamoorthy, Ashwin, Chandrapalan, Subashini, Bosch, Sofie, Bannaga, Ayman, De Boer, Nanne K H, De Meij, Tim G J, Leja, Marcis, Hanna, George B, De Vietro, Nicoletta, Altomare, Donato, Arasaradnam, Ramesh P
Format: Article
Language:English
Subjects:
Accuracy
Antigens
Biomarkers
Blood tests
Body Fluids
Breath Tests
Colonoscopy
Colorectal cancer
Diagnosis
DNA methylation
Gastrointestinal diseases
Gastrointestinal Diseases - diagnosis
Gene expression
Hemoglobin
Humans
Hydrocarbons
Identification and classification
Intestines
Literature reviews
Liver cancer
Measurement
mechanical bowel preparation
Metabolism
MicroRNAs
Physiological aspects
Production methods
Review
Signs and symptoms
Systematic review
Testing
Tumors
Urine
VOCs
volatile organic compound
Volatile Organic Compounds
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Summary:(1) Background: Colorectal cancer is the second commonest cause of cancer deaths worldwide; recently, volatile organic compounds (VOCs) have been proposed as potential biomarkers of this disease. In this paper, we aim to identify and review the available literature on the influence of mechanical bowel preparation on VOC production and measurement. (2) Methods: A systematic search for studies was carried out for articles relevant to mechanical bowel preparation and its effects on volatile organic compounds. A total of 4 of 1349 papers initially derived from the search were selected. (3) Results: Two studies with a total of 134 patients found no difference in measured breath VOC profiles after bowel preparation; one other study found an increase in breath acetone in 61 patients after bowel preparation, but no other compounds were affected. Finally, the last study showed the alteration of urinary VOC profiles. (4) Conclusions: There is limited data on the effect of bowel preparation on VOC production in the body. As further studies of VOCs are conducted in patients with symptoms of gastrointestinal disease, the quantification of the effect of bowel preparation on their abundance is required.
ISSN:1424-8220
1424-8220
DOI:10.3390/s23031377