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Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction
Objective This study sought to quantify the deep venous thrombosis (DVT) incidence in head and neck cancer (HNC) patients undergoing free tissue transfer and to identify independent predictors of postoperative DVT. Materials and Methods This is a cross‐sectional study of the National Surgical Qualit...
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| Published in: | Laryngoscope investigative otolaryngology 2023-12, Vol.8 (6), p.1584-1588 |
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| container_title | Laryngoscope investigative otolaryngology |
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| creator | Lee, Kevin C. Waring, Nicholas A. Yu, Victoria X. Okolo, Ogoegbunam Caruana, Salvatore M. Troob, Scott H. Parikh, Anuraag S. |
| description | Objective
This study sought to quantify the deep venous thrombosis (DVT) incidence in head and neck cancer (HNC) patients undergoing free tissue transfer and to identify independent predictors of postoperative DVT.
Materials and Methods
This is a cross‐sectional study of the National Surgical Quality Improvement Program database from 2010 through 2020. The sample included all HNC surgical patients treated with free flap reconstruction. The study outcome was the presence of a DVT requiring treatment within 30 days of surgery. Univariate analyses were performed using chi‐squared and independent t‐tests. A multiple logistic regression model was created using all significant univariate predictors.
Results
A total of 3954 patients were identified, of whom 53 (1.3%) experienced a postoperative DVT. The only medical comorbidity associated with DVT was COPD (RR = 2.7 [1.3, 5.4]; p |
| doi_str_mv | 10.1002/lio2.1189 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_e6ccc1eaa2d24fc8adf9fe144a19ae94</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e6ccc1eaa2d24fc8adf9fe144a19ae94</doaj_id><sourcerecordid>2903794580</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5779-d08cd771f836f253d001af5cb8b8da3cc9b919a364c5a854cf5a419212adeef03</originalsourceid><addsrcrecordid>eNp1kstuEzEUhkcIRKvSBS-ALLGBRVrfZsazQqgqEClSWcDaOrGPE4eJPdgzqfoOPDRO0ysSK1s-nz-fY_1V9ZbRM0YpP-995GeMqe5FdcxFq2aKCvXyyf6oOs15QyllDW8aRV9XR0IxQblsjqs_31PsY1ihJXHABKPfIRn9FsmQ0HozZjLEPD7WLOJAdhjilMm4TnG7jNln4gNZI1gCwZKA5hcxEAwmMpRbGIrleh3JFCymVSQuIRLXw0ASmhjymCYz-hjeVK8c9BlP79aT6ueXyx8X32aLq6_zi8-LmanbtptZqoxtW-aUaByvhS2jgavNUi2VBWFMt-xYB6KRpgZVS-NqkKzjjEPp3lFxUs0PXhtho4fkt5BudASvbw9iWmlIozc9amyMMQwBuOXSGQXWdQ6ZlFBewE4W16eDa5iWW7SmDJugfyZ9Xgl-rVdxpxltBZOqLoYPd4YUf0-YR7312WDfQ8Dyy5p3tK5ZKyUr6Pt_0E2cUih_tadE28la7cf7eKBMijkndA_dMKr3mdH7zOh9Zgr77mn7D-R9QgpwfgCufY83_zfpxfyK3yr_Aum2z_Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2903794580</pqid></control><display><type>article</type><title>Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction</title><source>PubMed (Medline)</source><source>Wiley_OA刊</source><source>ProQuest - Publicly Available Content Database</source><creator>Lee, Kevin C. ; Waring, Nicholas A. ; Yu, Victoria X. ; Okolo, Ogoegbunam ; Caruana, Salvatore M. ; Troob, Scott H. ; Parikh, Anuraag S.</creator><creatorcontrib>Lee, Kevin C. ; Waring, Nicholas A. ; Yu, Victoria X. ; Okolo, Ogoegbunam ; Caruana, Salvatore M. ; Troob, Scott H. ; Parikh, Anuraag S.</creatorcontrib><description>Objective
This study sought to quantify the deep venous thrombosis (DVT) incidence in head and neck cancer (HNC) patients undergoing free tissue transfer and to identify independent predictors of postoperative DVT.
Materials and Methods
This is a cross‐sectional study of the National Surgical Quality Improvement Program database from 2010 through 2020. The sample included all HNC surgical patients treated with free flap reconstruction. The study outcome was the presence of a DVT requiring treatment within 30 days of surgery. Univariate analyses were performed using chi‐squared and independent t‐tests. A multiple logistic regression model was created using all significant univariate predictors.
Results
A total of 3954 patients were identified, of whom 53 (1.3%) experienced a postoperative DVT. The only medical comorbidity associated with DVT was COPD (RR = 2.7 [1.3, 5.4]; p < .01). Operative time longer than 9 hours (RR = 1.9 [1.0, 3.2]; p = .04) and length of stay longer than 10 days (RR = 1.9 [1.1, 3.2]; p = .02) were associated with greater DVT rates. In the multivariate analysis, only COPD (p < .01) and operative time (p = .02) were independently associated with DVT risk. The presence of a DVT was found to increase the relative risk of readmission (RR = 2.1 [1.2, 3.6]; p < .01) and non‐home disposition (RR = 2.4 [1.7, 3.5]; p < .01).
Conclusions
The incidence of DVT in HNC free flap patients was comparable to what has been reported in the general population of HNC surgery patients. Operative time >9 h and COPD history were independent risk factors for DVT in this subset of patients. Symptomatic DVTs necessitating treatment were accompanied by poorer post‐hospitalization outcomes.
Level of Evidence
Level 3.
The American College of Surgeons National Surgical Quality Improvement Program database was analyzed for factors associated with postoperative deep venous thrombosis (DVT) in head and neck cancer patients undergoing free flap reconstruction. Out of 3954 patients, 1.3% experienced postoperative DVT requiring treatment. COPD and operative time >9 h were independent risk factors for this adverse outcome.</description><identifier>ISSN: 2378-8038</identifier><identifier>EISSN: 2378-8038</identifier><identifier>DOI: 10.1002/lio2.1189</identifier><identifier>PMID: 38130246</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cardiac arrest ; Chi-square test ; Datasets ; Diabetes ; flap physiology ; Head & neck cancer ; head and neck ; Head and Neck, and Tumor Biology ; Heart attacks ; Hospitalization ; Independent sample ; Length of stay ; Metastasis ; microvascular reconstruction and transplant surgery ; Original Research ; Patients ; Pulmonary embolisms ; Quality improvement ; Regression analysis ; Risk factors ; Thromboembolism ; Thrombosis</subject><ispartof>Laryngoscope investigative otolaryngology, 2023-12, Vol.8 (6), p.1584-1588</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of The Triological Society.</rights><rights>2023 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5779-d08cd771f836f253d001af5cb8b8da3cc9b919a364c5a854cf5a419212adeef03</citedby><cites>FETCH-LOGICAL-c5779-d08cd771f836f253d001af5cb8b8da3cc9b919a364c5a854cf5a419212adeef03</cites><orcidid>0000-0002-3079-1419 ; 0000-0001-6535-2056</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2903794580/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2903794580?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,37013,44590,46052,46476,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38130246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Kevin C.</creatorcontrib><creatorcontrib>Waring, Nicholas A.</creatorcontrib><creatorcontrib>Yu, Victoria X.</creatorcontrib><creatorcontrib>Okolo, Ogoegbunam</creatorcontrib><creatorcontrib>Caruana, Salvatore M.</creatorcontrib><creatorcontrib>Troob, Scott H.</creatorcontrib><creatorcontrib>Parikh, Anuraag S.</creatorcontrib><title>Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction</title><title>Laryngoscope investigative otolaryngology</title><addtitle>Laryngoscope Investig Otolaryngol</addtitle><description>Objective
This study sought to quantify the deep venous thrombosis (DVT) incidence in head and neck cancer (HNC) patients undergoing free tissue transfer and to identify independent predictors of postoperative DVT.
Materials and Methods
This is a cross‐sectional study of the National Surgical Quality Improvement Program database from 2010 through 2020. The sample included all HNC surgical patients treated with free flap reconstruction. The study outcome was the presence of a DVT requiring treatment within 30 days of surgery. Univariate analyses were performed using chi‐squared and independent t‐tests. A multiple logistic regression model was created using all significant univariate predictors.
Results
A total of 3954 patients were identified, of whom 53 (1.3%) experienced a postoperative DVT. The only medical comorbidity associated with DVT was COPD (RR = 2.7 [1.3, 5.4]; p < .01). Operative time longer than 9 hours (RR = 1.9 [1.0, 3.2]; p = .04) and length of stay longer than 10 days (RR = 1.9 [1.1, 3.2]; p = .02) were associated with greater DVT rates. In the multivariate analysis, only COPD (p < .01) and operative time (p = .02) were independently associated with DVT risk. The presence of a DVT was found to increase the relative risk of readmission (RR = 2.1 [1.2, 3.6]; p < .01) and non‐home disposition (RR = 2.4 [1.7, 3.5]; p < .01).
Conclusions
The incidence of DVT in HNC free flap patients was comparable to what has been reported in the general population of HNC surgery patients. Operative time >9 h and COPD history were independent risk factors for DVT in this subset of patients. Symptomatic DVTs necessitating treatment were accompanied by poorer post‐hospitalization outcomes.
Level of Evidence
Level 3.
The American College of Surgeons National Surgical Quality Improvement Program database was analyzed for factors associated with postoperative deep venous thrombosis (DVT) in head and neck cancer patients undergoing free flap reconstruction. Out of 3954 patients, 1.3% experienced postoperative DVT requiring treatment. COPD and operative time >9 h were independent risk factors for this adverse outcome.</description><subject>Cardiac arrest</subject><subject>Chi-square test</subject><subject>Datasets</subject><subject>Diabetes</subject><subject>flap physiology</subject><subject>Head & neck cancer</subject><subject>head and neck</subject><subject>Head and Neck, and Tumor Biology</subject><subject>Heart attacks</subject><subject>Hospitalization</subject><subject>Independent sample</subject><subject>Length of stay</subject><subject>Metastasis</subject><subject>microvascular reconstruction and transplant surgery</subject><subject>Original Research</subject><subject>Patients</subject><subject>Pulmonary embolisms</subject><subject>Quality improvement</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><issn>2378-8038</issn><issn>2378-8038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kstuEzEUhkcIRKvSBS-ALLGBRVrfZsazQqgqEClSWcDaOrGPE4eJPdgzqfoOPDRO0ysSK1s-nz-fY_1V9ZbRM0YpP-995GeMqe5FdcxFq2aKCvXyyf6oOs15QyllDW8aRV9XR0IxQblsjqs_31PsY1ihJXHABKPfIRn9FsmQ0HozZjLEPD7WLOJAdhjilMm4TnG7jNln4gNZI1gCwZKA5hcxEAwmMpRbGIrleh3JFCymVSQuIRLXw0ASmhjymCYz-hjeVK8c9BlP79aT6ueXyx8X32aLq6_zi8-LmanbtptZqoxtW-aUaByvhS2jgavNUi2VBWFMt-xYB6KRpgZVS-NqkKzjjEPp3lFxUs0PXhtho4fkt5BudASvbw9iWmlIozc9amyMMQwBuOXSGQXWdQ6ZlFBewE4W16eDa5iWW7SmDJugfyZ9Xgl-rVdxpxltBZOqLoYPd4YUf0-YR7312WDfQ8Dyy5p3tK5ZKyUr6Pt_0E2cUih_tadE28la7cf7eKBMijkndA_dMKr3mdH7zOh9Zgr77mn7D-R9QgpwfgCufY83_zfpxfyK3yr_Aum2z_Q</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Lee, Kevin C.</creator><creator>Waring, Nicholas A.</creator><creator>Yu, Victoria X.</creator><creator>Okolo, Ogoegbunam</creator><creator>Caruana, Salvatore M.</creator><creator>Troob, Scott H.</creator><creator>Parikh, Anuraag S.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3079-1419</orcidid><orcidid>https://orcid.org/0000-0001-6535-2056</orcidid></search><sort><creationdate>202312</creationdate><title>Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction</title><author>Lee, Kevin C. ; Waring, Nicholas A. ; Yu, Victoria X. ; Okolo, Ogoegbunam ; Caruana, Salvatore M. ; Troob, Scott H. ; Parikh, Anuraag S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5779-d08cd771f836f253d001af5cb8b8da3cc9b919a364c5a854cf5a419212adeef03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiac arrest</topic><topic>Chi-square test</topic><topic>Datasets</topic><topic>Diabetes</topic><topic>flap physiology</topic><topic>Head & neck cancer</topic><topic>head and neck</topic><topic>Head and Neck, and Tumor Biology</topic><topic>Heart attacks</topic><topic>Hospitalization</topic><topic>Independent sample</topic><topic>Length of stay</topic><topic>Metastasis</topic><topic>microvascular reconstruction and transplant surgery</topic><topic>Original Research</topic><topic>Patients</topic><topic>Pulmonary embolisms</topic><topic>Quality improvement</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kevin C.</creatorcontrib><creatorcontrib>Waring, Nicholas A.</creatorcontrib><creatorcontrib>Yu, Victoria X.</creatorcontrib><creatorcontrib>Okolo, Ogoegbunam</creatorcontrib><creatorcontrib>Caruana, Salvatore M.</creatorcontrib><creatorcontrib>Troob, Scott H.</creatorcontrib><creatorcontrib>Parikh, Anuraag S.</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley-Blackwell Free Backfiles(OpenAccess)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Laryngoscope investigative otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kevin C.</au><au>Waring, Nicholas A.</au><au>Yu, Victoria X.</au><au>Okolo, Ogoegbunam</au><au>Caruana, Salvatore M.</au><au>Troob, Scott H.</au><au>Parikh, Anuraag S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction</atitle><jtitle>Laryngoscope investigative otolaryngology</jtitle><addtitle>Laryngoscope Investig Otolaryngol</addtitle><date>2023-12</date><risdate>2023</risdate><volume>8</volume><issue>6</issue><spage>1584</spage><epage>1588</epage><pages>1584-1588</pages><issn>2378-8038</issn><eissn>2378-8038</eissn><abstract>Objective
This study sought to quantify the deep venous thrombosis (DVT) incidence in head and neck cancer (HNC) patients undergoing free tissue transfer and to identify independent predictors of postoperative DVT.
Materials and Methods
This is a cross‐sectional study of the National Surgical Quality Improvement Program database from 2010 through 2020. The sample included all HNC surgical patients treated with free flap reconstruction. The study outcome was the presence of a DVT requiring treatment within 30 days of surgery. Univariate analyses were performed using chi‐squared and independent t‐tests. A multiple logistic regression model was created using all significant univariate predictors.
Results
A total of 3954 patients were identified, of whom 53 (1.3%) experienced a postoperative DVT. The only medical comorbidity associated with DVT was COPD (RR = 2.7 [1.3, 5.4]; p < .01). Operative time longer than 9 hours (RR = 1.9 [1.0, 3.2]; p = .04) and length of stay longer than 10 days (RR = 1.9 [1.1, 3.2]; p = .02) were associated with greater DVT rates. In the multivariate analysis, only COPD (p < .01) and operative time (p = .02) were independently associated with DVT risk. The presence of a DVT was found to increase the relative risk of readmission (RR = 2.1 [1.2, 3.6]; p < .01) and non‐home disposition (RR = 2.4 [1.7, 3.5]; p < .01).
Conclusions
The incidence of DVT in HNC free flap patients was comparable to what has been reported in the general population of HNC surgery patients. Operative time >9 h and COPD history were independent risk factors for DVT in this subset of patients. Symptomatic DVTs necessitating treatment were accompanied by poorer post‐hospitalization outcomes.
Level of Evidence
Level 3.
The American College of Surgeons National Surgical Quality Improvement Program database was analyzed for factors associated with postoperative deep venous thrombosis (DVT) in head and neck cancer patients undergoing free flap reconstruction. Out of 3954 patients, 1.3% experienced postoperative DVT requiring treatment. COPD and operative time >9 h were independent risk factors for this adverse outcome.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38130246</pmid><doi>10.1002/lio2.1189</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3079-1419</orcidid><orcidid>https://orcid.org/0000-0001-6535-2056</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiac arrest Chi-square test Datasets Diabetes flap physiology Head & neck cancer head and neck Head and Neck, and Tumor Biology Heart attacks Hospitalization Independent sample Length of stay Metastasis microvascular reconstruction and transplant surgery Original Research Patients Pulmonary embolisms Quality improvement Regression analysis Risk factors Thromboembolism Thrombosis |
| title | Prolonged operative time predicts postoperative deep venous thrombosis in head and neck cancer patients who undergo free flap reconstruction |
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